Glycosaminoglycan reactivity in lupus as a predictor of disease

狼疮中的糖胺聚糖反应性作为疾病的预测因子

• 批准号: 7680340
• 负责人: FEI F SHIH
• 金额: $ 9.18万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7680340
• 关键词: Antibodies; Autoantibodies; Autoimmune Process; Biological Markers; Childhood; DNA Structure; Disease; Doctor of Medicine; Doctor of Philosophy; Feasibility Studies; Funding; Glycosaminoglycans; Lupus; Lupus Erythematosus; Modeling; Mus; Organ; Patients; Pattern; Pilot Projects; Production; Structure; Systemic Lupus Erythematosus; Title; base; cross reactivity; novel

Funded Pilot and Feasibility Study #2: Title: Glycosaminoglycan reactivity in lupus as a predictor of disease PI: Fei Shih, M.D., Ph.D. A. Specific Aims Systemic lupus erythematosus (SLE) is characterized by the production of autoantibodies and autoimmune attack of multiple organs. We hypothesized that there are novel targets yet to be discovered for SLE and these may serve as predictors of disease. Based on the highly patterned structure of DNA, we hypothesized that cross reactivity to glycosaminoglycans (GAGs), also a highly patterned structure, may serve as a biomarker for various disease manifestations. This pilot study examines aGAG reactivity in a murine model of SLE and extends aGAG analysis to pediatric patients with SLE with the following specific aims: 1) An unbiased examination of aGAG antibodies in KRN/G7m mice, a murine model of SLE; and 2) Characterize aGAG antibodies in SLE patients and correlation with disease.

资助试点和可行性研究#2： 标题：狼疮中的糖胺聚糖反应性作为疾病的预测因素 PI：Fei Shih，M.D.，博士 A.具体目标 系统性红斑狼疮（SLE）的特征在于自身抗体的产生， 多器官的自身免疫性攻击我们假设有新的靶点尚未被发现 发现SLE，这些可能作为疾病的预测。基于高度模式化的 DNA的结构，我们假设与糖胺聚糖（GAG）的交叉反应性，也是一种高度 图案化的结构，可以作为各种疾病表现的生物标志物。这项初步研究 在SLE小鼠模型中检查aGAG反应性，并将aGAG分析扩展至儿科 SLE患者，具有以下特定目的：1）aGAG抗体的无偏倚检查 在KRN/G7 m小鼠中，SLE的鼠模型;和2）表征SLE患者中的aGAG抗体 与疾病的相关性。