Functional Optical Coherence Tomography for Monitoring Drug Resistance in Cancer

用于监测癌症耐药性的功能光学相干断层扫描

基本信息

  • 批准号:
    8128195
  • 负责人:
  • 金额:
    $ 24.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-09-01 至 2013-08-31
  • 项目状态:
    已结题

项目摘要

Molecular signaling is a critical therapeutic target in cancer, and molecular therapeutics have achieved some success in treating a variety of cancers. However, our incomplete knowledge of pharmacodynamic effects in vivo limits the success of these molecular therapies. We have recently developed a new molecular imaging technique, photothermal optical coherence tomography (OCT), that extends the penetration depth of high resolution molecular Imaging beyond the microscopy limit. The current proposal will further develop photothermal OCT for in vivo imaging of cell receptors, and will combine this new technique with the hemodynamic imaging capabilities of Doppler OCT and spectral microscopy to provide a comprehensive picture of the pharmacodynamic effects of molecular cancer therapies in human cells grown into tumors in the mouse window chamber. The first aim will use a combined spectral / OCT microscope lo quantify changes in metabolic rate and hemodynamics with tumor growth. The second aim will develop photothermal OCT for in vivo imaging of cell receptors, and will quantify the pharmocodynamics of receptor inhibition in the mouse window chamber. The final aim will combine OCT and microscopy to quantify longitudinal changes in receptor expression and hemodyanmic / metabolic response to combination therapies in mouse window chamber tumors. These studies will establish our novel hemodynamic, metabolic and molecular imaging techniques as high resolution, three-dimensional drug screening methods for preclinical applications. This multi-disciplinary environment will provide an excellent opportunity for professional growth and scientific advancement.
分子信号是治疗癌症的一个重要靶点,分子治疗已经取得了一些进展

项目成果

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Melissa Caroline Skala其他文献

Melissa Caroline Skala的其他文献

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{{ truncateString('Melissa Caroline Skala', 18)}}的其他基金

Development and Validation of Photothermal Optical Coherence Tomography for Retinal Imaging
用于视网膜成像的光热光学相干断层扫描的开发和验证
  • 批准号:
    10550200
  • 财政年份:
    2022
  • 资助金额:
    $ 24.75万
  • 项目类别:
Development and Validation of Photothermal Optical Coherence Tomography for Retinal Imaging
用于视网膜成像的光热光学相干断层扫描的开发和验证
  • 批准号:
    10380391
  • 财政年份:
    2022
  • 资助金额:
    $ 24.75万
  • 项目类别:
Optical imaging of pancreas cancer organoids for drug development and personalized treatment
胰腺癌类器官的光学成像用于药物开发和个性化治疗
  • 批准号:
    9388210
  • 财政年份:
    2017
  • 资助金额:
    $ 24.75万
  • 项目类别:
Optical imaging of pancreas cancer organoids for drug development and personalized treatment
胰腺癌类器官的光学成像用于药物开发和个性化治疗
  • 批准号:
    10223218
  • 财政年份:
    2017
  • 资助金额:
    $ 24.75万
  • 项目类别:
Optical imaging of pancreas cancer organoids for drug development and personalized treatment
胰腺癌类器官的光学成像用于药物开发和个性化治疗
  • 批准号:
    9769226
  • 财政年份:
    2017
  • 资助金额:
    $ 24.75万
  • 项目类别:
(PQ7) Quantitative in vivo optical imaging of tumor heterogeneity
(PQ7) 肿瘤异质性的定量体内光学成像
  • 批准号:
    9323359
  • 财政年份:
    2016
  • 资助金额:
    $ 24.75万
  • 项目类别:
Cellular level optical metabolic imaging to predict drug response in cancer
细胞水平光学代谢成像预测癌症药物反应
  • 批准号:
    9298127
  • 财政年份:
    2014
  • 资助金额:
    $ 24.75万
  • 项目类别:
Cellular level optical metabolic imaging to predict drug response in cancer
细胞水平光学代谢成像预测癌症药物反应
  • 批准号:
    9767107
  • 财政年份:
    2014
  • 资助金额:
    $ 24.75万
  • 项目类别:
Cellular level optical metabolic imaging to predict drug response in cancer
细胞水平光学代谢成像预测癌症药物反应
  • 批准号:
    9138626
  • 财政年份:
    2014
  • 资助金额:
    $ 24.75万
  • 项目类别:
Functional Optical Coherence Tomography for Monitoring Drug Resistance in Cancer
用于监测癌症耐药性的功能光学相干断层扫描
  • 批准号:
    8307913
  • 财政年份:
    2010
  • 资助金额:
    $ 24.75万
  • 项目类别:

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Molecular Epidemiological and pathological studies on the association between lipoprotein(a) and malignant neoplasms
脂蛋白(a)与恶性肿瘤关系的分子流行病学及病理学研究
  • 批准号:
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  • 财政年份:
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  • 批准号:
    6116914
  • 财政年份:
    1998
  • 资助金额:
    $ 24.75万
  • 项目类别:
GENETIC PREDISPOSITION TO SECOND MALIGNANT NEOPLASMS FOLLOWING CHILDHOOD
儿童期后第二次恶性肿瘤的遗传倾向
  • 批准号:
    6219852
  • 财政年份:
    1998
  • 资助金额:
    $ 24.75万
  • 项目类别:
GENETIC PREDISPOSITION TO SECOND MALIGNANT NEOPLASMS FOLLOWING CHILDHOOD
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  • 批准号:
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  • 财政年份:
    1996
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    $ 24.75万
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SECOND MALIGNANT NEOPLASMS FOLLOWING CANCER OF THE OVARY
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