Mechanisms of Mutant Epidermal Growth Factor Receptor Induced Lung Tumorigenesis

表皮生长因子受体突变诱导肺肿瘤发生的机制

• 批准号: 8099855
• 负责人: KATERINA Abigail POLITI
• 金额: $ 24.9万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8099855
• 关键词: Address; Affect; Alleles; Arginine; Award; Behavior; Cancer Biology; Cancer Model; Cells; Clinical; Data; Development; Doxycycline; ERBB2 gene; Epidermal Growth Factor Receptor; Epithelial Cells; Epithelium; Erlotinib; Exons; Family; Family member; Gefitinib; Gene Dosage; Gene Expression; Gene Expression Alteration; Genes; Genetic; Genomics; Goals; Human; Knowledge; Lead; Lesion; Leucine; Lung; Lung Adenocarcinoma; Lung Neoplasms; Maintenance; Malignant Neoplasms; Malignant neoplasm of lung; Mediating; Memorial Sloan-Kettering Cancer Center; Mentors; Mus; Mutation; Non-Small-Cell Lung Carcinoma; Oncogenic; Patients; Pharmaceutical Preparations; Phenotype; Phosphotransferases; Point Mutation; Positioning Attribute; Program Development; Relapse; Relative (related person); Research; Research Proposals; Resistance; Resources; Role; Sampling; Scientist; Specimen; Tertiary Protein Structure; Testing; Tetracyclines; Training; Training Programs; Transgenic Mice; Transgenic Organisms; Tumor Suppressor Genes; Tyrosine Kinase Domain; Tyrosine Kinase Inhibitor; Withdrawal; alveolar type II cell; base; career; career development; clinical phenotype; genetic analysis; lung carcinogenesis; lung tumorigenesis; member; mouse model; mutant; novel; overexpression; programs; response; skills; time use; transgene expression; tumor; tumor initiation; tumorigenesis