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Mechanisms of Mutant Epidermal Growth Factor Receptor Induced Lung Tumorigenesis

Mechanisms of Mutant Epidermal Growth Factor Receptor Induced Lung Tumorigenesis
表皮生长因子受体突变诱导肺肿瘤发生的机制
批准号：
8110489
负责人：
KATERINA Abigail POLITI
金额：
$24.15万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-09-01 至 2013-06-30
来源：
https://reporter.nih.gov/project-details/8110489
关键词：
AccountingAddressAffectAnimalsAttentionAwardBehaviorCancer ModelCancer PatientCandidate Disease GeneCellsCollaborationsCollectionComprehensive Cancer CenterDataData SetDevelopmentDiseaseDisease ResistanceDoxycyclineDrug resistanceEmbryoEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor Tyrosine Kinase InhibitorEpithelial CellsEpitheliumExonsFamilyFamily memberGefitinibGene DosageGene ExpressionGene Expression AlterationGenesGeneticGenomicsGoalsGoatGrantHeterozygoteHomozygoteHumanIncidenceKnockout MiceKnowledgeLeadLesionLungLung AdenocarcinomaLung NeoplasmsLymphomaMaintenanceMalignant NeoplasmsMalignant neoplasm of lungMediatingMemorial Sloan-Kettering Cancer CenterMentorsModelingMolecular ProfilingMusMutationNon-Small-Cell Lung CarcinomaOncogenesOncogenicPathologyPathway interactionsPatientsPharmaceutical PreparationsPhasePhenotypePhosphatidylinositolsPositioning AttributeProcessProtocols documentationPublishingReceptor Protein-Tyrosine KinasesReceptor SignalingRelapseResearchResearch ProposalsResistanceResourcesRoleSamplingScientistSpecimenTestingTetracyclinesTimeTransgenic MiceTransgenic OrganismsTumor Cell LineTumor Suppressor GenesTumor Suppressor ProteinsTyrosine Kinase InhibitorUniversitiesValidationWithdrawalWorkbasecancer genomicscareer developmentclinical phenotypecohortgenetic analysisin vivolung carcinogenesislung tumorigenesismeetingsmembermouse modelmutantnoveloverexpressionprofessorprogramsresearch studyresistance mechanismresponsesarcomasuccesstransgene expressiontumortumorigenesis

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