Mechanisms of Mutant Epidermal Growth Factor Receptor Induced Lung Tumorigenesis

表皮生长因子受体突变诱导肺肿瘤发生的机制

• 批准号: 8110489
• 负责人: KATERINA Abigail POLITI
• 金额: $ 24.15万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8110489
• 关键词: Accounting; Address; Affect; Animals; Attention; Award; Behavior; Cancer Model; Cancer Patient; Candidate Disease Gene; Cells; Collaborations; Collection; Comprehensive Cancer Center; Data; Data Set; Development; Disease; Disease Resistance; Doxycycline; Drug resistance; Embryo; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor; Epithelial Cells; Epithelium; Exons; Family; Family member; Gefitinib; Gene Dosage; Gene Expression; Gene Expression Alteration; Genes; Genetic; Genomics; Goals; Goat; Grant; Heterozygote; Homozygote; Human; Incidence; Knockout Mice; Knowledge; Lead; Lesion; Lung; Lung Adenocarcinoma; Lung Neoplasms; Lymphoma; Maintenance; Malignant Neoplasms; Malignant neoplasm of lung; Mediating; Memorial Sloan-Kettering Cancer Center; Mentors; Modeling; Molecular Profiling; Mus; Mutation; Non-Small-Cell Lung Carcinoma; Oncogenes; Oncogenic; Pathology; Pathway interactions; Patients; Pharmaceutical Preparations; Phase; Phenotype; Phosphatidylinositols; Positioning Attribute; Process; Protocols documentation; Publishing; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Relapse; Research; Research Proposals; Resistance; Resources; Role; Sampling; Scientist; Specimen; Testing; Tetracyclines; Time; Transgenic Mice; Transgenic Organisms; Tumor Cell Line; Tumor Suppressor Genes; Tumor Suppressor Proteins; Tyrosine Kinase Inhibitor; Universities; Validation; Withdrawal; Work; base; cancer genomics; career development; clinical phenotype; cohort; genetic analysis; in vivo; lung carcinogenesis; lung tumorigenesis; meetings; member; mouse model; mutant; novel; overexpression; professor; programs; research study; resistance mechanism; response; sarcoma; success; transgene expression; tumor; tumorigenesis