Characterization of cartilage using magnetic resonance imaging and kinematics in

使用磁共振成像和运动学表征软骨

• 批准号: 8102417
• 负责人: Sharmila Majumdar
• 金额: $ 29.78万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8102417
• 关键词: Age; Biochemical; Biological Markers; Biomechanics; Bone Marrow; Cartilage; Characteristics; Collagen; Complex; Degenerative polyarthritis; Development; Diagnosis; Disease; Disease Progression; Dyskinetic syndrome; Evolution; Gait; Health; Hip Joint; Hip Osteoarthritis; Hip region structure; Image; Individual; Joints; Kinetics; Knee; Lesion; Link; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Measurement; Measures; Monitor; Morphology; Motion; Movement; Outcome; Pain; Pathogenesis; Patients; Pattern; Preventive; Proteoglycan; Relaxation; Reporting; Risk; Role; Scientist; Severity of illness; Staging; Structure; Synovial Membrane; Testing; Thick; Time; Tissues; Translations; Water; Work; articular cartilage; base; bone; clinical practice; disability; kinematics; novel; radiologist; spatiotemporal; tool

Recently, magnetic resonance (MR) T2 and T1p relaxation time measurements have emerged as potential markers for early biochemical cartilage degeneration, and thus may be important when examining the pathogenesis of OA. Additionally, changes in kinematics, kinetics, spatiotemporal gait characteristics and functional activities have been reported in patients with early hip OA. The proposed study aims to investigate biochemical differences that may be seen in mild and moderate radiographic hip OA using MRI, exploring their relation to kinematics and function. It also aims to explore cartilage degeneration and progression of hip OA longitudinally, and establish the relationship between changes in composition and the development of morphological lesions. Our central hypothesis is that image-based measures of hip cartilage biochemical composition differs between controls and patients with hip OA, and are related to cartilage morphology, hip biomechanics, pain, function and severity of disease. To test this hypothesis, this study will 1) characterize hip cartilage composition (measured by MRI Tip and T2 relaxation times) in patients with hip OA, compared to controls, 2) determine the cross-sectional and longitudinal relationship between hip cartilage composition and morphology, and 3) determine whether hip cartilage composition is related to patient function (kinematics, kinetics, spatiotemporal gait characteristics, functional tests) and pain (WOMAC), both cross-sectionally and longitudinally. The results of the proposed study will help determine whether early biochemical degeneration in cartilage, as quantified by T2 and T1p mapping parameters, is associated with the progression of hip OA and is related to hip OA outcomes such as detriments in patient function. By evaluating the interrelationship between MR markers of compositional changes in OA and movement patterns during functional tasks, this study provides an essential link between tissue structure and function in the hip joint. In this proposal, an interdisciplinary team extends their extensive prior work in the knee, and to elucidate the complex interactions of abnormal movement patterns, cartilage biochemical and morphologic degeneration during the progression and outcomes of hip OA.

最近，磁共振(MR)T2和T1p弛豫时间测量已经成为潜在的 早期生化软骨退变的标志物，因此在检查 骨性关节炎的发病机制。此外，运动学、动力学、时空步态特征和 据报道，早期髋关节骨性关节炎患者有功能活动。这项拟议的研究旨在调查 应用MRI研究轻、中度髋关节骨关节炎患者的生化差异 它们与运动学和功能的关系。它还旨在探索髋关节软骨的退变和进展 并建立了成分变化与骨质疏松症发展之间的关系 形态上的损伤。我们的中心假设是基于图像的髋关节软骨生化测量 对照组和髋关节骨性关节炎患者的成分不同，并与软骨形态、髋关节有关。 生物力学、疼痛、功能和疾病严重程度。为了验证这一假设，这项研究将1)表征 髋关节骨性关节炎患者的髋关节软骨成分(用MRI Tip和T2松弛时间测量)的比较 作为对照，2)确定髋关节软骨成分之间的横断面和纵向关系 和形态，以及3)确定髋关节软骨成分是否与患者功能有关 (运动学、动力学、时空步态特征、功能测试)和疼痛(WOMAC)，两者都 横截面和纵向。拟议的研究结果将有助于确定早期 通过T2和T1p定位参数量化的软骨生化退化与 髋关节骨性关节炎的进展，与髋关节骨性关节炎的结局有关，如患者功能受损。通过 评价骨关节炎成分改变的MR标志物与运动的相互关系 在功能任务中的模式，这项研究提供了组织结构和功能之间的重要联系 髋关节。在这份提案中，一个跨学科团队将他们先前广泛的工作延伸到膝盖上，并 阐明异常运动模式与软骨生化和形态的复杂相互作用 髋关节骨性关节炎进展和结局过程中的退行性改变。