COBRE: UID: PILOT: SELENIUM HOMEOSTASIS AND ANXIETY: THE ROLE OF THE GENOTYPE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 硒（Se）是一种必需的微量元素，对维持正常的大脑功能至关重要 在人类和其他脊椎动物中。硒缺乏导致许多神经和生理 赤字，引起相当大的兴趣，关于硒补充的潜在好处。在 特别是，有一些证据表明，硒补充剂具有有益的心理健康影响 包括减少焦虑。然而，补充硒对人体的影响 行为和情绪是有争议的;虽然一些研究将硒状态与焦虑联系起来， 其他人没有发现这种效果。 我们假设基因型与环境的相互作用可以解释相互矛盾的结果 关于人体补硒的功效。虽然基因型的概念， 环境相互作用对进化生物学家来说并不新鲜， 个人和群体现在才成为有效医疗的关键因素 (i.e.“个性化医疗”）。研究遗传学的遗传基础和进化相关性 在人类中，对硒补充的反应的变化是困难的，需要 使用模式生物。在这里，我们认为，我们的行为不同的菌株， 斑马鱼是理想的模型系统，其中种群特异性反应的遗传基础 可以研究硒的补充。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Selenium (Se) is an essential trace element that is critical for maintaining normal brain function in humans and other vertebrates. Se deficiency causes numerous neurological and physiological deficits, eliciting considerable interest regarding the potential benefits of Se supplementation. In particular, there is some evidence that Se supplementation has beneficial mental health effects in humans, including decreased anxiety. However, the effects of Se supplementation on human behavior and mood are controversial; while several studies have linked Se status to anxiety, others have found no such effect. We hypothesize that a genotype by environment interaction may explain the conflicting results regarding the efficacy of Se supplementation in humans. While the concept of a genotype by environment interaction is not new to evolutionary biologists, genetic variation among individuals and populations is only now becoming a key factor in effective medical treatment (i.e. "personalized medicine"). Studying the genetic basis and evolutionary relevance of genetic variation in the response to Se supplementation is difficult in humans, necessitating an approach using model organisms. Here we argue that our behaviorally distinct strains of zebrafish are the ideal model system in which the genetic basis of a population specific response to Se supplementation can be studied.