COBRE: UID: PILOT: SELENIUM HOMEOSTASIS AND ANXIETY: THE ROLE OF THE GENOTYPE

COBRE：UID：飞行员：硒稳态和焦虑：基因型的作用

• 批准号: 8359578
• 负责人: BARRIE D ROBISON
• 金额: $ 3.32万
• 依托单位: UNIVERSITY OF IDAHO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359578
• 关键词: Animal Model; Anxiety; Behavior; Biological Models; Brain; Centers of Research Excellence; Conflict (Psychology); Environment; Evolution; Funding; Genetic; Genetic Variation; Genotype; Grant; Homeostasis; Human; Individual; Link; Medical; Medicine; Mental Health; Moods; National Center for Research Resources; Neurologic; Physiological; Population; Principal Investigator; Process; Research; Research Infrastructure; Resources; Role; Selenium; Source; Supplementation; Trace Elements; United States National Institutes of Health; Vertebrates; Zebrafish; base; cost; interest; response; selenium deficiency

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Selenium (Se) is an essential trace element that is critical for maintaining normal brain function in humans and other vertebrates. Se deficiency causes numerous neurological and physiological deficits, eliciting considerable interest regarding the potential benefits of Se supplementation. In particular, there is some evidence that Se supplementation has beneficial mental health effects in humans, including decreased anxiety. However, the effects of Se supplementation on human behavior and mood are controversial; while several studies have linked Se status to anxiety, others have found no such effect. We hypothesize that a genotype by environment interaction may explain the conflicting results regarding the efficacy of Se supplementation in humans. While the concept of a genotype by environment interaction is not new to evolutionary biologists, genetic variation among individuals and populations is only now becoming a key factor in effective medical treatment (i.e. "personalized medicine"). Studying the genetic basis and evolutionary relevance of genetic variation in the response to Se supplementation is difficult in humans, necessitating an approach using model organisms. Here we argue that our behaviorally distinct strains of zebrafish are the ideal model system in which the genetic basis of a population specific response to Se supplementation can be studied.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 硒是一种必需的微量元素，对维持大脑正常功能至关重要。 在人类和其他脊椎动物身上。硒缺乏导致许多神经和生理方面的问题 这引起了人们对补充硒的潜在好处的相当大的兴趣。在……里面 特别是，有一些证据表明，补充硒对心理健康有好处。 在人类身上，包括减少焦虑。然而，补硒对人体的影响 行为和情绪是有争议的；虽然有几项研究将硒状况与焦虑联系在一起， 其他人则没有发现这样的效果。 我们假设，基因与环境的交互作用可以解释相互矛盾的结果。 关于补硒对人类的功效。虽然基因型别的概念由 环境相互作用对进化生物学家来说并不新鲜，基因变异在 个人和人口现在才成为有效医疗的关键因素 (即“个性化医疗”)。研究基因的遗传基础和进化相关性 人类对硒补充的反应很难发生变化，这就需要 使用模型生物体的方法。在这里，我们认为我们在行为上不同的品系 斑马鱼是一种理想的模式系统，在该系统中，种群特异性反应的遗传基础 可以对补硒进行研究。