Influence of moderate hearing loss on auditory perception & cortical processing

中度听力损失对听觉感知的影响

• 批准号: 8115864
• 负责人: Dan Harvey Sanes
• 金额: $ 30.81万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115864
• 关键词: ARHGEF5 gene; Acoustics; Address; Adolescence; Adolescent; Adult; Affect; Animals; Auditory; Auditory Perception; Auditory area; Behavior; Behavioral; Brain; Child; Code; Communication; Conductive hearing loss; Control Animal; Cues; Data; Data Analyses; Detection; Development; Frequencies; Gerbils; Goals; Hearing; Human; Individual; Laboratories; Language Development; Lead; Measurable; Measures; Metric; Nervous System Physiology; Neuraxis; Neurons; Operant Conditioning; Pattern; Perception; Performance; Process; Property; Proteinase 3; ST5 gene; Sensorineural Hearing Loss; Sensory; Shapes; Signal Transduction; Stimulus; Structure; Synaptic Membranes; Testing; Time; Training; Work; awake; base; ear infection; early experience; experience; hearing impairment; improved; juvenile animal; middle ear; neurodevelopment; public health relevance; relating to nervous system; response; skills; sound; theories

DESCRIPTION (provided by applicant): Many auditory perceptual skills mature over a long time course (in humans), well into the teenage years. If hearing is disrupted during development, there may be long-lasting deficits in auditory perception and language acquisition. Surprisingly, maturation of the auditory coding properties that support late-emerging perceptual skills are largely unknown; what little we do know is based solely on recordings from anesthetized animals. This is also why our understanding of the effect of mild to moderate hearing loss on central auditory maturation is unsettled. To address these issues, I will examine functional development in awake animals for the first time, and explore how auditory coding properties are influenced by sensory experience. The central hypothesis is that moderate hearing loss during development disrupts coding properties in the auditory cortex (ACx), leading to measurable deficits in auditory perceptual performance. There are three related aims: AIM 1 will determine whether developmental conductive hearing loss disrupts the perceptual abilities of adult gerbils. Animals will be tested on two tasks that, in humans, are known to have different rates of maturation and to be affected by hearing loss. These include detection of sinusoidal amplitude (sAM) and frequency modulated (sFM) signals. AIM 2 will determine whether training on an auditory task during juvenile development can rescue normal perceptual behavior in animals reared with conductive hearing loss. AIM 3 will characterize the normal rate of development of neural coding properties underlying the percepts examined in Aim 1, and will assess whether these coding properties are perturbed in a manner that correlates with perceptual deficits examined in AIM 1. Single unit recordings will be obtained from the ACx of awake animals during the period of development that follows cochlear maturation. The broad goals are to determine whether coding properties mature at different rates, as suggested by behavioral studies, and to determine whether sAM or sFM coding is vulnerable to early hearing loss. Together, these data will provide the first analysis of auditory coding in awake developing animals, and reveal whether moderate hearing loss disrupts both perceptual skills and the coding properties that support them. PUBLIC HEALTH RELEVANCE: Profound hearing loss in children can produce long-lasting deficits in auditory perception and language acquisition, and it has been suggested that mild to moderate hearing loss, including that commonly associated with middle ear infections, might also impact auditory performance. To address this question, we will induce conductive hearing loss in developing animals, and study their behavioral performance and central auditory nervous system function as adults. Thus, this study will examine whether moderate hearing loss disrupts both perceptual skills and the neural coding properties that support them.

描述（由申请人提供）：许多听觉感知技能在很长一段时间内（人类）成熟，直到青少年时期。如果听力在发育过程中受到干扰，听觉感知和语言习得可能会出现长期缺陷。令人惊讶的是，支持后期出现的感知技能的听觉编码特性的成熟在很大程度上是未知的;我们所知道的很少是完全基于麻醉动物的录音。这也是为什么我们对轻度至中度听力损失对中枢听觉成熟的影响的理解是不确定的。为了解决这些问题，我将首次研究清醒动物的功能发育，并探索听觉编码特性如何受到感官体验的影响。核心假设是，在发育过程中中度听力损失破坏了听觉皮层（ACx）的编码特性，导致听觉感知性能的可测量缺陷。有三个相关的目标：AIM 1将确定发育性传导性听力损失是否会破坏成年沙鼠的感知能力。动物将接受两项任务的测试，在人类中，已知这两项任务具有不同的成熟速度，并受到听力损失的影响。这些包括检测正弦幅度（sAM）和频率调制（sFM）信号。AIM 2将确定在幼年发育期间进行听觉任务训练是否可以挽救传导性听力损失动物的正常感知行为。AIM 3将表征目标1中检查的感知背后的神经编码特性的正常发育速率，并将评估这些编码特性是否以与AIM 1中检查的感知缺陷相关的方式受到干扰。在耳蜗成熟后的发育期间，将从清醒动物的ACx获得单个单位记录。广泛的目标是确定编码特性是否以不同的速率成熟，如行为研究所建议的那样，并确定sAM或sFM编码是否易受早期听力损失的影响。这些数据将共同提供对清醒发育动物听觉编码的首次分析，并揭示中度听力损失是否会破坏感知技能和支持它们的编码特性。 公共卫生关系：儿童严重的听力损失会在听觉感知和语言习得方面产生长期的缺陷，并且已经表明轻度至中度听力损失，包括通常与中耳感染相关的听力损失，也可能影响听觉表现。为了解决这个问题，我们将在发育中的动物中诱导传导性听力损失，并研究它们成年后的行为表现和中枢听觉神经系统功能。因此，本研究将研究中度听力损失是否会破坏感知技能和支持它们的神经编码特性。