Infectious Triggers in Chronic Fatigue Syndrome

描述（由申请人提供）：慢性疲劳综合征（CFS）是一种病因不明的主要致残疾病。它直接影响到400多万美国人。传染性病原体被高度怀疑，但没有一种被证实。发现它们的障碍是缺乏一种广泛的方法，既可以检测单个样品中存在的多种微生物，又可以检测新的或变异的微生物。由于99%以上的微生物无法培养，可能无法被发现，这进一步阻碍了这一进程。与过去的限制相比，我们将采用一种能够克服这些障碍的新方法。在CFS脑脊液中发现潜在病原体将改变该疾病的研究方法和可能的早期发现、预防和治疗。这可能是产生新假设并开始调查微生物的因果关系以及预防（鸡蛋疫苗）或抵消微生物病原体影响的方法的门户步骤。

DESCRIPTION (provided by applicant): Chronic Fatigue Syndrome (CFS) is a major disabling illness of unknown etiology. It directly impacts more than four million Americans. Infectious agents have been highly suspected but none have ever been validated. Obstacles to their discovery have been lack of a broad approach that can both detect the presence of multiple microbes in a single sample and detect novel or variants of microbes. This has been further hampered because more than 99% of all microbes cannot be cultured and may go undetected. In contrast to past limitations, we will use a new approach that can surmount these obstacles. The discovery of potential pathogens in cerebrospinal fluid of CFS would be field-altering in terms of approach to the study of the disease and possible early detection, prevention and treatment. This could be the gateway step to generate new hypotheses and begin investigation into a microbe's causal association and ways to prevent (egg vaccine) or counteract the effects of a microbial pathogen.