UPITT Program for Pharmaceutical Outcomes Research in Aging

描述（由申请人提供）：本K07的总体目标是在UPITT的强大资源基础上建立一个强大的研究和研究培训衰老药物成果研究（PORA）。PORA的具体目标是：1)创建一个教育系列，为老年药物结果研究建立坚实的知识和技能基础；2)建立一支训练有素的实地调查干部队伍；3)为医药数据管理和分析提供经验学习和支持。为了支持目标一，我们将开发并提供：1)作为临床与转化科学研究所（CTSI）证书、硕士和博士研究生课程的一部分，开设一个新的9学分的老年药物结果研究集中领域；2)每月一次的老年药学成果研究研讨会，3)每年一次的客座教授；4)在美国老年学会年度会议上举办关于老年药物疗效研究的年度会前研讨会。为了支持第二个目标，我召集了一群高级和初级教师导师。学员将从多个层面招募（初级教员、博士后研究员、住院医师和博士生前实习生），来自多个学科，包括药学、医学、流行病学、卫生服务研究和其他领域，并通过我们的附属医疗保健系统（UPMC和VA）、CTSI、胡椒中心和NIA培训补助金的现有资金支持。我们每年也会提供一个小规模的试点奖励。为了支持目标三，一名资深生物统计学家教员将为上述学员提供研究设计和统计支持。执行委员会由PI、生物统计学家和NIA资助的胡椒中心的PI组成，T32和T35项目将提供行政和智力领导。该方案将由一个多学科的内部咨询委员会监督，以确保该方案与包括技术支助方案在内的联合技术援助方案资源很好地结合和利用。候选人是老年药物治疗研究领域的领导者，也是一名忠诚的教师和导师。本K07提案的长期目标是获得T32和/或中心/项目拨款，以培训未来的研究人员进行重要的研究，通过改善药物的安全性和使用来增强老年人的健康。该方案得到了强有力的体制支持，以确保其短期和长期的成功。相关性（见说明书）：老年患者是人口中快速增长的一部分，他们通常会经历药物相关问题。需要新的调查人员和更多的多学科药物结局研究来发现、更好地了解、预防或减少老年人的药物相关问题。

DESCRIPTION (provided by applicant): The overall goal of this K07 is to build a strong research and research training Pharmaceutical Outcomes Research in Aging (PORA on the strong foundation of resources at UPITT. The PORA specific aims are to: 1) create an educational series that builds a solid foundation of knowledge and skills in geriatric pharmaceutical outcomes research; 2) build a cadre of well trained investigators in the field; and 3) provide experiential learning and support for data management and analysis of pharmaceutical data. In support of aim one, we will develop and provide: 1) a new 9 credit Area of Concentration in Geriatric Pharmaceutical Outcomes Research as part of the Clinical and Translational Science Institute's (CTSI) certificate, masters and PhD graduate programs; 2) a credit bearing monthly geriatric pharmaceutical outcomes research seminar, 3) an annual Visiting Professorship; and 4) an annual pre-meeting workshop on Geriatric Pharmaceutical Outcomes Research at the annual Gerontological Society of America meeting. In support of aim two, I have assembled a group of senior and junior faculty mentors. Trainees will be recruited at multiple levels (junior faculty, post doctoral fellows, residents, and pre-doctoral student trainees), come from multiple disciplines including pharmacy, medicine, epidemiology, health services research and other fields and be supported through existing funding from our affiliated health care systems (UPMC and VA), the CTSI, Pepper Center and our NIA training grants. We will annually also offer a small pilot award. In support of aim three, a senior biostatistician faculty member will provide study design and statistical support for the above- mentioned trainees. An Executive Committee consisting of the PI, the biostatistician and the PI of the NIA- funded Pepper Center and T32 and T35 programs will provide administrative and intellectual leadership. The PORA will be overseen by a multidisciplinary Internal Advisory Committee to assure that the PORA is well integrated with and leverages UPITT resources including the CTSI. The candidate is a leader in the field of geriatric pharmacotherapy research and a committed teacher and mentor to beginning investigators. The long term goal of this K07 proposal is to secure a T32 and/or center/program grant to train future researchers to conduct important research to enhance the health of older adults by improving the safety and use of medications. There is strong institutional support for the PORA to assure its short and long term success. RELEVANCE (See instructions): Older patients represent a rapidly increasing segment of the population that commonly experiences medication-related problems. New investigators and additional multidisciplinary pharmaceutical outcomes research are needed to detect, better understand, prevent or reduce, medication-related problems in older adults.