UPITT Program for Pharmaceutical Outcomes Research in Aging

描述（由申请人提供）：本K 07的总体目标是在UPITT强大的资源基础上建立一个强大的研究和研究培训老龄化药物结局研究（PORA）。PORA的具体目标是：1）创建一个教育系列，为老年药物成果研究奠定坚实的知识和技能基础; 2）在该领域建立一支训练有素的研究人员队伍; 3）为数据管理和药物数据分析提供经验学习和支持。为了支持目标一，我们将开发和提供：1）一个新的9学分的老年药物成果研究集中领域，作为临床和转化科学研究所（CTSI）证书，硕士和博士研究生课程的一部分; 2）每月一次的老年药物成果研究研讨会，3）每年一次的客座教授;和4）在美国老年学会年会上举行的老年药物成果研究年会前研讨会。为了支持第二个目标，我召集了一批高年级和低年级的教师导师。学员将在多个层次（初级教师，博士后研究员，居民和博士前学生学员）招聘，来自多个学科，包括药学，医学，流行病学，卫生服务研究和其他领域，并通过我们附属的医疗保健系统（UPMC和VA），CTSI，胡椒中心和我们的NIA培训赠款的现有资金支持。我们每年还将提供一个小的试点奖。为了支持目标三，一名高级生物统计学家教员将为上述学员提供研究设计和统计支持。由PI、生物统计学家和NIA资助的胡椒中心PI以及T32和T35项目组成的执行委员会将提供行政和智力领导。PORA将由一个多学科内部咨询委员会监督，以确保PORA与包括CTSI在内的UPITT资源良好整合并充分利用这些资源。候选人是老年药物治疗研究领域的领导者，也是一名致力于开始研究的教师和导师。该K 07提案的长期目标是获得T32和/或中心/计划资助，以培训未来的研究人员进行重要的研究，通过改善药物的安全性和使用来增强老年人的健康。为确保《保护和救济法》的短期和长期成功，有强有力的机构支持。相关性（参见说明）：老年患者代表了通常经历药物相关问题的人口的快速增长部分。需要新的研究人员和额外的多学科药物结果研究来检测，更好地理解，预防或减少老年人的药物相关问题。

DESCRIPTION (provided by applicant): The overall goal of this K07 is to build a strong research and research training Pharmaceutical Outcomes Research in Aging (PORA on the strong foundation of resources at UPITT. The PORA specific aims are to: 1) create an educational series that builds a solid foundation of knowledge and skills in geriatric pharmaceutical outcomes research; 2) build a cadre of well trained investigators in the field; and 3) provide experiential learning and support for data management and analysis of pharmaceutical data. In support of aim one, we will develop and provide: 1) a new 9 credit Area of Concentration in Geriatric Pharmaceutical Outcomes Research as part of the Clinical and Translational Science Institute's (CTSI) certificate, masters and PhD graduate programs; 2) a credit bearing monthly geriatric pharmaceutical outcomes research seminar, 3) an annual Visiting Professorship; and 4) an annual pre-meeting workshop on Geriatric Pharmaceutical Outcomes Research at the annual Gerontological Society of America meeting. In support of aim two, I have assembled a group of senior and junior faculty mentors. Trainees will be recruited at multiple levels (junior faculty, post doctoral fellows, residents, and pre-doctoral student trainees), come from multiple disciplines including pharmacy, medicine, epidemiology, health services research and other fields and be supported through existing funding from our affiliated health care systems (UPMC and VA), the CTSI, Pepper Center and our NIA training grants. We will annually also offer a small pilot award. In support of aim three, a senior biostatistician faculty member will provide study design and statistical support for the above- mentioned trainees. An Executive Committee consisting of the PI, the biostatistician and the PI of the NIA- funded Pepper Center and T32 and T35 programs will provide administrative and intellectual leadership. The PORA will be overseen by a multidisciplinary Internal Advisory Committee to assure that the PORA is well integrated with and leverages UPITT resources including the CTSI. The candidate is a leader in the field of geriatric pharmacotherapy research and a committed teacher and mentor to beginning investigators. The long term goal of this K07 proposal is to secure a T32 and/or center/program grant to train future researchers to conduct important research to enhance the health of older adults by improving the safety and use of medications. There is strong institutional support for the PORA to assure its short and long term success. RELEVANCE (See instructions): Older patients represent a rapidly increasing segment of the population that commonly experiences medication-related problems. New investigators and additional multidisciplinary pharmaceutical outcomes research are needed to detect, better understand, prevent or reduce, medication-related problems in older adults.