Cue-triggered reward seeking

提示触发奖励寻求

• 批准号: 8094369
• 负责人: Kent C. Berridge
• 金额: $ 33.38万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8094369
• 关键词: Abstinence; Agonist; Amygdaloid structure; Animal Model; Animals; Behavior; Behavioral; Binge Eating; Binge eating disorder; Brain; Cell Nucleus; Cocaine; Conditioned Stimulus; Contralateral; Cues; Desire for food; Dopamine; Drug Addiction; Drug Sensitization; Eating; Eating Disorders; Food; Functional disorder; Generations; Goals; Health; Human; Hunger; Incentives; Individual; Laboratory Study; Learning; Light; Location; Maps; Measurable; Measures; Mediating; Memory; Methods; Microinjections; Motivation; Nucleus Accumbens; Opioid; Pharmaceutical Preparations; Property; Rattus; Relapse; Relative (related person); Rewards; Role; Smoker; Sodium; Sodium Chloride; Specificity; Stimulus; Structure; Sucrose; System; Techniques; Testing; Time; addiction; base; classical conditioning; conditioning; craving; design; drinking; drug addict; drug reward; hedonic; insight; mesolimbic system; neglect; neurochemistry; neuromechanism; psychologic; relating to nervous system; research study; tool

DESCRIPTION (provided by applicant): Recovering drug addicts encounter danger when faced with drug-related cues or contexts, because those situations can trigger relapse. Similarly, bouts of binge eating are often triggered by cues for food relevant rewards. Cues are especially potent triggers when individuals are in vulnerable states. These proposal aims to identify the brain states that cause vulnerability to cue-triggered 'wanting' of reward. The responsible brain mechanisms particularly involve the limbic nucleus accumbens and amygdala. Here we will study how these brain mechanisms cause excessive incentive salience ('wanting') to be attributed to particular reward cues. In experiment 1, microinjections of agonist drugs and a Fos plume mapping tool will be used to identify the neural mechanisms in nucleus accumbens and amygdala that magnify cue-triggered 'wanting'. In experiment 2, the circuit principles that join together the nucleus accumbens and amygdala into a cooperative system will be identified by manipulating the structures with multiple simultaneous microinjections. In experiment 3, prior neural sensitization and learning manipulations will help show how natural 'wanting' mechanisms are usurped by drugs and sensitization to cause an addicted reward to be 'wanted' more than other rewards. These studies will help clarify the brain and psychological mechanisms that cause addicts to excessively 'want' drug and binge eaters to excessively 'want' food rewards. PUBLIC HEALTH RELEVANCE: A primary problem in drug addiction and binge eating disorders is the continuing danger for relapse posed by encounters with cues for the addicted reward (even after long periods of abstinence). A brain mechanism has been hypothesized to cause cue-triggered relapse, namely incentive sensitization of brain systems that generate normal 'wanting' for rewards. The studies proposed here will help reveal those brain mechanisms underlying cue-triggered relapse, and will shed light on how compulsive 'wants' are produced in addiction and in eating disorders.

描述（由申请人提供）：恢复吸毒成瘾者遇到危险时，面对与毒品有关的线索或背景，因为这些情况可能引发复发。同样，暴饮暴食的发作通常是由食物相关奖励的线索引发的。当个体处于脆弱状态时，线索是特别有效的触发器。这些建议旨在确定导致线索触发的“想要”奖励的大脑状态。负责的大脑机制特别涉及边缘核、杏仁核和杏仁核。在这里，我们将研究这些大脑机制如何导致过度的激励显着性（“想要”）归因于特定的奖励线索。在实验1中，激动剂药物的显微注射和Fos羽映射工具将被用来确定放大线索触发的“想要”的杏仁核和杏仁核的神经机制。在实验2中，通过同时进行多次显微注射来操纵结构，将丘脑核和杏仁核连接在一起形成一个合作系统的电路原理将被确定。在实验3中，先前的神经敏化和学习操作将有助于显示自然的“想要”机制是如何被药物和敏化所篡夺，从而导致成瘾奖励比其他奖励更“想要”。这些研究将有助于阐明导致成瘾者过度“想要”药物和暴食者过度“想要”食物奖励的大脑和心理机制。公共卫生相关性：药物成瘾和暴食症的一个主要问题是持续的复发危险，这是由于遇到成瘾奖励的线索（即使在长时间禁欲之后）。一种大脑机制被假设为导致线索触发的复发，即大脑系统的激励敏感化，产生正常的“想要”奖励。这里提出的研究将有助于揭示那些潜在的线索触发复发的大脑机制，并将揭示强迫性“欲望”是如何在成瘾和饮食失调中产生的。