Cue-triggered reward seeking

提示触发奖励寻求

• 批准号: 8288230
• 负责人: Kent C. Berridge
• 金额: $ 33.38万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8288230
• 关键词: Abstinence; Agonist; Amygdaloid structure; Animal Model; Animals; Behavior; Behavioral; Binge Eating; Binge eating disorder; Brain; Cell Nucleus; Cocaine; Conditioned Stimulus; Contralateral; Cues; Desire for food; Dopamine; Drug Addiction; Drug Sensitization; Eating; Eating Disorders; Food; Functional disorder; Generations; Goals; Human; Hunger; Incentives; Individual; Laboratory Study; Learning; Light; Location; Maps; Measurable; Measures; Mediating; Memory; Methods; Microinjections; Motivation; Nucleus Accumbens; Opioid; Pharmaceutical Preparations; Property; Rattus; Relapse; Relative (related person); Rewards; Role; Smoker; Sodium; Sodium Chloride; Specificity; Stimulus; Structure; Sucrose; System; Techniques; Testing; Time; abstracting; addiction; base; classical conditioning; conditioning; craving; design; drinking; drug addict; drug reward; hedonic; insight; mesolimbic system; neglect; neurochemistry; neuromechanism; psychologic; relating to nervous system; research study; tool

Abstract Recovering drug addicts encounter danger when faced with drug-related cues or contexts, because those situations can trigger relapse. Similarly, bouts of binge eating are often triggered by cues for food relevant rewards. Cues are especially potent triggers when individuals are in vulnerable states. These proposal aims to identify the brain states that cause vulnerability to cue-triggered 'wanting' of reward. The responsible brain mechanisms particularly involve the limbic nucleus accumbens and amygdala. Here we will study how these brain mechanisms cause excessive incentive salience ('wanting') to be attributed to particular reward cues. In experiment 1, microinjections of agonist drugs and a Fos plume mapping tool will be used to identify the neural mechanisms in nucleus accumbens and amygdala that magnify cue-triggered 'wanting'. In experiment 2, the circuit principles that join together the nucleus accumbens and amygdala into a cooperative system will be identified by manipulating the structures with multiple simultaneous microinjections. In experiment 3, prior neural sensitization and learning manipulations will help show how natural 'wanting' mechanisms are usurped by drugs and sensitization to cause an addicted reward to be 'wanted' more than other rewards. These studies will help clarify the brain and psychological mechanisms that cause addicts to excessively 'want' drug and binge eaters to excessively 'want' food rewards.

摘要 康复中的吸毒者在面对与毒品相关的线索或 因为这些情况可能会引发复发。同样，暴饮暴食 通常是由食物相关奖励的线索触发的。线索是特别有效的触发器 当人们处于脆弱状态时。这些建议旨在识别大脑 导致容易受到线索触发的“想要”奖励的状态。负责 大脑机制特别涉及到大脑边缘核和杏仁核。 在这里我们将研究这些大脑机制是如何引起过度激励显著性的 （“想要”）归因于特定的奖励线索。在实验1中， 激动剂药物和Fos羽映射工具将用于识别神经 杏仁核和杏仁核中放大线索触发的“欲望”的机制。 在实验2中，将原子核的电子束连接在一起的电路原理， 杏仁核到一个合作系统将被确定通过操纵的结构 同时进行多次显微注射在实验3中，预先神经敏化 学习操纵将有助于展示自然的“想要”机制 被毒品和敏感性篡夺，导致上瘾的奖励被“想要”超过 其他奖励。这些研究将有助于阐明大脑和心理机制 导致瘾君子过度“想要”毒品和暴食者过度“想要”食物 奖励