CTSA INFRASTRUCTURE FOR PEDATRIC AIDS RESEARCH

CTSA 儿科艾滋病研究基础设施

• 批准号: 8173924
• 负责人: JILL G JOSEPH
• 金额: $ 77.17万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173924
• 关键词: Research; Research Infrastructure

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. After a decade of remarkable research growth and institutional investment, Children's National Medical Center (CNMC) builds on significant strategic recruitments, reorganizations, and collaborations required to create the transformative capabilities of the Clinical and Translational Science Institute at Children's National (CTSI-CN). It has done so in partnership with its academic affiliate, the George Washington University. The specific objectives of our application are to: 1) Provide state-of-the-art, flexible resources required by CTR investigators; 2) Promote multidisciplinary clinical and translational research (CTR); 3) Strengthen CTR education and training for diverse trainees at all stages of career development; 4) Promote demographic diversity and address health disparities; 5) Incorporate effective and sustained collaboration with community partners; 6) Assure efficiency of CTR from conceptualization through dissemination; and 7) Establish bi-directional collaborations with the CTSA network. The CTSI-CN has innovative features including: a child health focus, especially emphasizing health disparities and childhood antecedents of adult diseases; our relationship with a national network of 1200 community health centers, and in TI strengths in rare diseases and neurodevelopmental disabilities. We have combined certain related CTSA components to provide more closely integrated, investigator-focused capabilities. Biomedical Informatics (BI): provides the backbone informatics support to all CTSI-CN components. Research Education, Training and Career Development (RETCD) integrates, supports, and expands CTR education and training so that it is available from high school through mid-career. A new degree program (MS in CTR) and a certificate program are complemented by diverse educational opportunities for faculty, trainees, and staff at all levels of experience. Specialized programs are available for mid-level faculty to promote their career advancement and mentoring capabilities, and for underrepresented minority undergraduates potentially interested in a career in CTR. Community Engagement and Research/Health Policy (CER/HP) integrates traditional community engagement/research with nationally recognized health policy capabilities. Participant and Clinical Interactions Resources (PCIR) transforms our existing GCRC into a nimble and innovative resource that supports participant interactions at diverse locations including CNMC, outpatient facilities, GW, and the community. Pilot and Collaborative Translational and Clinical Studies: supports transfomiative ideas by investigators at all career levels. Novel Clinical and Translational Methodologies (NCTM) identifies needs and gaps and supports development of innovative methodologies, especially to support TTR cores. Research Design. Epidemiology, Biostatistics, and Clinical Research Ethics/Regulatory Knowledge and Support (DBE/RKS): provides integrated, investigator-focused resources to assure the quality of research and the protection of human subjects at all stages of research. Translational Technologies and Resources (TTR) supports a diverse group of 15 core functions. Tracking and Evaluation (TE): CTSI-CN activities will be guided and modified by a thoughtful and detailed evaluation plan. RELEVANCE (See Instructions): The CTSI-CN provides highly integrated, cost effective, investigator-focused resources designed to overcome obstacles to investigation, promote collaborative research, and be continuously monitored and evaluated to identify when further adaptation or modification is needed. Located in the nation's capital and serving a population of children and families disproportionately affected by health disparities, the CTSI-CN brings to bear unique resources in translating discovery to improved health, particularly in our most disadvantaged populations of children.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 经过十年显著的研究增长和机构投资，国家儿童医学中心(CNMC)建立在重大战略招聘、重组和合作的基础上，以创建国家儿童临床和转化科学研究所(CTSI-CN)的转型能力为基础。它是与其学术附属机构乔治华盛顿大学合作做到这一点的。我们的应用程序的具体目标是：1)提供CTR研究人员所需的最先进、灵活的资源；2)促进多学科临床和转化性研究(CTR)；3)在职业发展的所有阶段加强对不同受训人员的CTR教育和培训；4)促进人口多样性和解决健康差距；5)纳入与社区合作伙伴的有效和持续的合作；6)确保CTR从概念到传播的效率；以及7)与CTSA网络建立双向合作。CTSI-CN具有创新功能，包括：以儿童健康为重点，特别强调健康差距和儿童时期成人疾病的先兆；我们与全国1200个社区卫生中心网络的关系，以及TI在罕见疾病和神经发育障碍方面的优势。我们结合了某些相关的CTSA组件，以提供更紧密集成的、以调查员为重点的能力。生物医学信息学(BI)：为CTSI-CN的所有组件提供主干信息学支持。研究型教育、培训和职业发展(RETCD)整合、支持和扩展了CTR教育和培训，以便从高中到职业生涯中期都可以使用。一项新的学位计划(CTR硕士)和一项证书计划得到了各种教育机会的补充，这些机会面向所有经验水平的教职员工、实习生和工作人员。为促进中层教师的职业发展和指导能力，以及对可能对CTR感兴趣的未被充分代表的少数族裔本科生，提供专门的课程。社区参与和研究/卫生政策(CER/HP)将传统的社区参与/研究与国家认可的卫生政策能力相结合。参与者和临床互动资源(PCIR)将我们现有的GCRC转变为一个灵活和创新的资源，支持不同地点的参与者互动，包括CNMC、门诊设施、GW和社区。试点和协作性翻译和临床研究：支持所有职业水平的研究人员转变想法。新的临床和转化方法(NCTM)确定需求和差距，并支持创新方法的开发，特别是支持TTR核心。研究设计。流行病学、生物统计学和临床研究伦理/监管知识和支持(DBE/RKS)：提供以研究人员为中心的综合资源，以确保研究质量并在研究的所有阶段保护人类受试者。翻译技术和资源(TTR)支持15个核心功能的不同组。跟踪和评价(TE)：CTSI-CN的活动将由深思熟虑和详细的评价计划指导和修改。相关性(见说明)：CTSI-CN提供高度整合、成本效益高、以调查员为重点的资源，旨在克服调查障碍，促进合作研究，并持续监测和评估，以确定何时需要进一步适应或修改。CTSI-CN位于美国首都，服务于受健康差距影响不成比例的儿童和家庭，在将发现转化为改善健康方面具有独特的资源，特别是在我们最弱势的儿童群体中。