RESEARCH CORE

概述随着时间的推移，我们的研究小组开展了所有活动，目的是改善少数群体的健康状况，消除健康差距，特别注重儿童健康。在上一个供资周期中进行的研究侧重于基本描述性调查，其特点是在表征遗传、行为和环境因素的共同和交互作用方面具有显著创新。尽管如下面讨论的那样构成了重大挑战，但这一努力一直是 非常成功。随着招聘工作的最终敲定，具体结果将继续显现，但这种多学科调查现在得到了更广泛的赞赏和支持。例如，慈善基金正在支持P20资助的研究(Eric Hoffman，见下文)，受该中心影响的多名调查人员现在正在将更复杂、更细微和多学科的方法纳入他们的差异研究。值得注意的例子包括在艾滋病毒/艾滋病患者中使用坚持工作的药理学措施 非裔美国青少年的应对和坚持研究(R.LaGrange)，程博士在国家儿童研究中的工作重点是阐明歧视和压力在幼儿时期产生差异的生物机制，并将应激反应的生理学测量纳入暴力暴露影响的R01研究(J.Joseph)。也许更重要的是，一项研究 小组吸引了许多人参与儿童健康研究，并对我们的参与机构产生了积极影响。 为了扩大和加强我们的工作，我们提议支持纳入生命历程视角的干预研究，重点放在关键时期(青春期)(具体目标1)，并创建一个儿童健康差距联盟(具体目标2)。为了支持这一请求，我们在下文中介绍了RCCHD在前一个供资期间的进展情况以及实现这些目标的HC4HF计划。 4.1.2实现具体目标1和4的目标：成功的衡量标准我们将跟踪具体的衡量标准，以确保我们的研究活动取得成功。 1.确保通过中心进行的R01研究成功实施严谨 调查。如下文所述，研究核心将实施具体的监测和监督活动，以确保拟议的高影响力研究取得成功。这将包括：在初次提交后4个月内获得内部审计委员会的批准；在实施前建立双方一致同意的每月招聘目标；在研究实施的头12个月内实现60%的目标，在第二个12个月及以后的12个月内实现80%的目标；在实施的前12个月将自然减员限制在不超过30%，在第二个12个月及以后的12个月内减少25%；在资金的头12个月为数据收集和分析提供信息技术支持。 2.成功成立儿童健康差距研究联盟。要跟踪的具体指标包括：在供资的头12个月建立财团，包括第一次会议；在供资的第2年建立定期会议；在供资的第12个月制定咨询资源的区域财务分析；从第2年开始，每月建立和维持“智囊团”活动；以及 与培训和社区核心协作，每年举办五次网络研讨会，从#年开始 6个月的资金。 3.通过儿童健康组织的活动扩大严格的儿童健康差距研究 差异研究联盟。在五年的资助期内，我们将跟踪以下情况 指标：将与儿童健康差距相关的拨款申请数量增加至少25% 资助前12个月的提交数量；增加资助项目的数量 (NIH、其他联邦、基金会)使用相同的基线至少减少25%；实现至少5 纳入儿童健康差距研究的研究职业发展奖；增加 关于儿童健康差距的出版物数量比 在资助前12个月，至少有25份出版物引用了HC4HF中心的支持 太棒了。

Overview Our research group has undertaken all of its activities over time with the goal of improving minority health and eliminating health disparities with a specific focus on child health. Research conducted during the last funding cycle focused on basic descriptive investigations characterized by remarkable innovation in characterizing the joint and interactive contributions of genetic, behavioral, and environmental factors are disparities. Although posing significant challenges as discussed below, this effort has been remarkably successful. Specific results will continue to emerge as recruitment is finalized, but such multidisciplinary investigations now are more widely appreciated and supported. For example, philanthropic funding is sustaining P20-supported research (Eric Hoffman, see below) and multiple investigators influenced by the center are now incorporating more complex, nuanced, and multi-disciplinary approaches into their disparities research. Notable examples include use of pharmacologic measures of adherence into work in HIV/AIDS coping and adherence studies among African-American adolescents (R. LaGrange), work by Dr. Cheng within the National Children Study focused on elucidating biologic mechanisms by which discrimination and stress produce disparities in early childhood, and the incorporation of physiologic measures of stress reactivity into R01 research on the effects of violence exposure (J. Joseph). Perhaps even more importantly, a research group has attracted many to child health research and positively impacted our participating institutions. To extend and strengthen our work, we propose to support intervention research incorporating a life course perspective with a focus on a critical period (adolescence) (Specific Aim 1) and to create a Child Health Disparities Consortium (Specific Aim 2). In support of this request, we describe below RCCHD progress in the prior funding period and the HC4HF plans for achieving these aims. 4.1.2 Objectives to achieve Specific Aims 1 and 4: Metrics of Success We will track specific metrics to assure the success of our research activities. 1. Assure success of R01 research conducted through the center in implementing rigorous investigations. As described below, the Research Core will implement specific monitoring and oversight activities in order to assure the success of the high-impact research which is proposed. This will include: achieving IRB approval within 4 months of initial submission; establishing consensually agreed upon monthly recruitment targets prior to implementation; achieving 60% of these targets in the first 12 months of study implementation, and 80% in the second 12 months and following; limiting attrition to no more than 30% in the first 12 months of implementation, and 25% in the second 12 months and following; establishing IT support for data collection and analysis in the first 12 months of funding. 2. Successfully establish the Child Health Disparities Research Consortium. Specific metrics to be tracked include: establishing the consortium in the first 12 months of funding, including an initial meeting; establishing regular meetings by Year 2 of funding; developing an RFA for consultative resources by month 12 of funding; beginning Year 2, monthly "think tank" activities instituted and sustained; and collaboration with the Training and Community Cores to conduct five webinars per year, beginning in month 6 of funding. 3. Expand rigorous child health disparities research through the activities of the Child Health Disparities Research Consortium. Over the five year period of funding we will track the following metrics: increase the number of grant submissions relevant to child health disparities by at least 25% over the number of submissions in the 12 months preceding funding; increase the number of funded projects (NIH, other federal, foundation) by at least 25% using the same baseline; achieve funding for at least 5 Research Career Development Awards incorporating child health disparities research; increase the number of publications on child health disparities by at least 25% over the number of submissions in the 12 months preceding funding with at least 25 publications citing support ofthe HC4HF Center of Excellence.