RESEARCH CORE

研究核心

• 批准号: 8853950
• 负责人: JILL G JOSEPH
• 金额: $ 11.67万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8853950
• 关键词: AIDS/HIV problem; Address; Adherence; Adolescence; Adolescent; Adult; Affect; African American; Baltimore; Behavioral Genetics; Child; Child health care; Collaborations; Communities; Complex; Data Analyses; Data Collection; Discrimination; District of Columbia; Emerging Technologies; Environment; Environmental Risk Factor; Exposure to; Fostering; Foundations; Funding; Future; Goals; Grant; Health; Healthy People 2020; Institutes; Institution; Institutional Review Boards; Intervention; Intervention Studies; Investigation; Joints; K-Series Research Career Programs; Lead; Life Cycle Stages; Link; Measures; Monitor; National Children' s Study; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Philanthropic Fund; Physiological; Publications; Research; Research Activity; Research Personnel; Research Support; Research Training; Resources; Stress; Testing; Text; Time; Training; United States National Institutes of Health; Violence; Work; base; coping; critical developmental period; critical period; early childhood; experience; health disparity; health equity; improved; innovation; intergenerational; mHealth; meetings; minority health; multidisciplinary; programs; stress reactivity; success; symposium

Overview Our research group has undertaken all of its activities over time with the goal of improving minority health and eliminating health disparities with a specific focus on child health. Research conducted during the last funding cycle focused on basic descriptive investigations characterized by remarkable innovation in characterizing the joint and interactive contributions of genetic, behavioral, and environmental factors are disparities. Although posing significant challenges as discussed below, this effort has been remarkably successful. Specific results will continue to emerge as recruitment is finalized, but such multidisciplinary investigations now are more widely appreciated and supported. For example, philanthropic funding is sustaining P20-supported research (Eric Hoffman, see below) and multiple investigators influenced by the center are now incorporating more complex, nuanced, and multi-disciplinary approaches into their disparities research. Notable examples include use of pharmacologic measures of adherence into work in HIV/AIDS coping and adherence studies among African-American adolescents (R. LaGrange), work by Dr. Cheng within the National Children Study focused on elucidating biologic mechanisms by which discrimination and stress produce disparities in early childhood, and the incorporation of physiologic measures of stress reactivity into R01 research on the effects of violence exposure (J. Joseph). Perhaps even more importantly, a research group has attracted many to child health research and positively impacted our participating institutions. To extend and strengthen our work, we propose to support intervention research incorporating a life course perspective with a focus on a critical period (adolescence) (Specific Aim 1) and to create a Child Health Disparities Consortium (Specific Aim 2). In support of this request, we describe below RCCHD progress in the prior funding period and the HC4HF plans for achieving these aims. 4.1.2 Objectives to achieve Specific Aims 1 and 4: Metrics of Success We will track specific metrics to assure the success of our research activities. 1. Assure success of R01 research conducted through the center in implementing rigorous investigations. As described below, the Research Core will implement specific monitoring and oversight activities in order to assure the success of the high-impact research which is proposed. This will include: achieving IRB approval within 4 months of initial submission; establishing consensually agreed upon monthly recruitment targets prior to implementation; achieving 60% of these targets in the first 12 months of study implementation, and 80% in the second 12 months and following; limiting attrition to no more than 30% in the first 12 months of implementation, and 25% in the second 12 months and following; establishing IT support for data collection and analysis in the first 12 months of funding. 2. Successfully establish the Child Health Disparities Research Consortium. Specific metrics to be tracked include: establishing the consortium in the first 12 months of funding, including an initial meeting; establishing regular meetings by Year 2 of funding; developing an RFA for consultative resources by month 12 of funding; beginning Year 2, monthly "think tank" activities instituted and sustained; and collaboration with the Training and Community Cores to conduct five webinars per year, beginning in month 6 of funding. 3. Expand rigorous child health disparities research through the activities of the Child Health Disparities Research Consortium. Over the five year period of funding we will track the following metrics: increase the number of grant submissions relevant to child health disparities by at least 25% over the number of submissions in the 12 months preceding funding; increase the number of funded projects (NIH, other federal, foundation) by at least 25% using the same baseline; achieve funding for at least 5 Research Career Development Awards incorporating child health disparities research; increase the number of publications on child health disparities by at least 25% over the number of submissions in the 12 months preceding funding with at least 25 publications citing support ofthe HC4HF Center of Excellence.

概述我们的研究小组一直在开展所有活动，目标是改善少数民族健康，消除健康差距，特别关注儿童健康。在上一个资助周期进行的研究集中在基本的描述性调查，其特点是显着的创新，在表征遗传，行为和环境因素的联合和互动的贡献是差异。尽管如下文所述，这一努力带来了重大挑战，但它一直是一项艰巨的任务。 非常成功随着征聘工作的最后完成，将继续产生具体结果，但这种多学科调查现在得到更广泛的赞赏和支持。例如，慈善基金正在维持P20支持的研究（埃里克霍夫曼，见下文），受该中心影响的多个研究人员现在正在将更复杂，细致入微和多学科的方法纳入他们的差异研究。值得注意的例子包括在艾滋病毒/艾滋病工作中使用药物措施 应对和坚持的研究在非洲裔美国青少年（R。拉格朗日），郑博士在全国儿童研究中的工作重点是阐明歧视和压力在幼儿期产生差异的生物机制，并将压力反应的生理措施纳入关于暴力暴露影响的R 01研究（J. Joseph）。也许更重要的是，一项研究 该小组吸引了许多人参与儿童健康研究，并对我们的参与机构产生了积极影响。 为了扩大和加强我们的工作，我们建议支持干预研究，将生命过程的观点与重点放在关键时期（青春期）（具体目标1），并创建一个儿童健康差异联盟（具体目标2）。为了支持这一要求，我们在下文中描述了RCCHD在前一个供资期的进展情况以及HC 4 HF为实现这些目标而制定的计划。 4.1.2实现具体目标1和4的目标：成功的保证我们将跟踪具体的指标，以确保我们的研究活动的成功。 1.确保通过中心进行的R 01研究的成功， 调查事务所如下所述，研究中心将开展具体的监测和监督活动，以确保拟议的高影响力研究取得成功。这将包括：在首次提交后4个月内获得IRB批准;在实施前建立一致同意的每月招募目标;在研究实施的前12个月内实现这些目标的60%，在第二个12个月及以后实现80%;在实施的头12个月内，将人员流失限制在不超过30%，在第二个12个月及以后的时间内，将人员流失限制在不超过25%;在供资的头12个月，为数据收集和分析提供信息技术支持。 2.成功建立儿童健康差异研究联盟。需要跟踪的具体指标包括：在供资的头12个月建立联合体，包括举行一次首次会议;在供资的第2年建立定期会议;在供资的第12个月建立一个咨询资源外地住房储备金;从第2年开始，每月开展并维持“智囊团”活动;以及 与培训和社区核心合作，每年举办五次网络研讨会， 第六个月融资。 3.通过儿童健康中心的活动，扩大对儿童健康差距的严格研究 差异研究联盟。在五年的资助期内，我们将跟踪以下内容 指标：将与儿童健康差距相关的赠款提交数量增加至少25%， 在资助前12个月内提交的项目数量;增加资助项目的数量 (NIH、其他联邦、基金会）使用相同基线至少增加25%;实现至少5 研究职业发展奖纳入儿童健康差异研究;增加 关于儿童健康差异的出版物数量比《公约》提交的数量至少增加25%。 资助前12个月，至少有25篇出版物引用了HC 4 HF中心的支持 卓越