CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

CTSA 儿科研究基础设施

• 批准号: 8173922
• 负责人: JILL G JOSEPH
• 金额: $ 38.58万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173922
• 关键词: Pediatric Research; Research Infrastructure

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. After a decade of remarkable research growth and institutional investment, Children's National Medical Center (CNMC) builds on significant strategic recruitments, reorganizations, and collaborations required to create the transformative capabilities of the Clinical and Translational Science Institute at Children's National (CTSI-CN). It has done so in partnership with its academic affiliate, the George Washington University. The specific objectives of our application are to: 1) Provide state-of-the-art, flexible resources required by CTR investigators; 2) Promote multidisciplinary clinical and translational research (CTR); 3) Strengthen CTR education and training for diverse trainees at all stages of career development; 4) Promote demographic diversity and address health disparities; 5) Incorporate effective and sustained collaboration with community partners; 6) Assure efficiency of CTR from conceptualization through dissemination; and 7) Establish bi-directional collaborations with the CTSA network. The CTSI-CN has innovative features including: a child health focus, especially emphasizing health disparities and childhood antecedents of adult diseases; our relationship with a national network of 1200 community health centers, and in TI strengths in rare diseases and neurodevelopmental disabilities. We have combined certain related CTSA components to provide more closely integrated, investigator-focused capabilities. Biomedical Informatics (BI): provides the backbone informatics support to all CTSI-CN components. Research Education, Training and Career Development (RETCD) integrates, supports, and expands CTR education and training so that it is available from high school through mid-career. A new degree program (MS in CTR) and a certificate program are complemented by diverse educational opportunities for faculty, trainees, and staff at all levels of experience. Specialized programs are available for mid-level faculty to promote their career advancement and mentoring capabilities, and for underrepresented minority undergraduates potentially interested in a career in CTR. Community Engagement and Research/Health Policy (CER/HP) integrates traditional community engagement/research with nationally recognized health policy capabilities. Participant and Clinical Interactions Resources (PCIR) transforms our existing GCRC into a nimble and innovative resource that supports participant interactions at diverse locations including CNMC, outpatient facilities, GW, and the community. Pilot and Collaborative Translational and Clinical Studies: supports transfomiative ideas by investigators at all career levels. Novel Clinical and Translational Methodologies (NCTM) identifies needs and gaps and supports development of innovative methodologies, especially to support TTR cores. Research Design. Epidemiology, Biostatistics, and Clinical Research Ethics/Regulatory Knowledge and Support (DBE/RKS): provides integrated, investigator-focused resources to assure the quality of research and the protection of human subjects at all stages of research. Translational Technologies and Resources (TTR) supports a diverse group of 15 core functions. Tracking and Evaluation (TE): CTSI-CN activities will be guided and modified by a thoughtful and detailed evaluation plan. RELEVANCE (See Instructions): The CTSI-CN provides highly integrated, cost effective, investigator-focused resources designed to overcome obstacles to investigation, promote collaborative research, and be continuously monitored and evaluated to identify when further adaptation or modification is needed. Located in the nation's capital and serving a population of children and families disproportionately affected by health disparities, the CTSI-CN brings to bear unique resources in translating discovery to improved health, particularly in our most disadvantaged populations of children.

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 经过十年的显着研究增长和机构投资，儿童国家医疗中心（CNMC）建立在重要的战略招聘，重组和合作，以创建儿童国家临床和转化科学研究所（CTSI-CN）的变革能力。它是与其学术分支机构乔治华盛顿大学合作开展这项工作的。我们申请的具体目标是：1）提供CTR研究者所需的最先进的，灵活的资源; 2）促进多学科临床和转化研究（CTR）; 3）加强CTR教育和培训，为不同的学员在职业发展的各个阶段; 4）促进人口多样性和解决健康差距; 5）与社区合作伙伴进行有效和持续的合作; 6）确保CTR从概念化到传播的效率; 7）与CTSA网络建立双向合作。CTSI-CN具有创新功能，包括：关注儿童健康，特别强调健康差异和成人疾病的儿童前因;我们与全国1200个社区卫生中心网络的关系，以及TI在罕见疾病和神经发育障碍方面的优势。我们已经结合了某些相关的CTSA组件，以提供更紧密集成的、以干扰器为重点的功能。生物医学信息学（BI）：为所有CTSI-CN组件提供骨干信息学支持。研究教育，培训和职业发展（RETCD）整合，支持和扩展CTR教育和培训，使其从高中到职业生涯中期都可用。一个新的学位课程（在CTR MS）和证书课程是由教师，学员和工作人员在经验的各个层次的多样化的教育机会的补充。专业课程可供中级教师，以促进他们的职业发展和指导能力，并为代表性不足的少数民族本科生可能有兴趣在CTR的职业生涯。社区参与和研究/卫生政策（CER/HP）将传统的社区参与/研究与国家认可的卫生政策能力相结合。参与者和临床互动资源（PCIR）将我们现有的GCRC转变为一个灵活的创新资源，支持参与者在不同地点的互动，包括CNMC，门诊设施，GW和社区。试点和协作转化和临床研究：支持所有职业水平的研究者的创新想法。新型临床和转化方法（NCTM）确定需求和差距，并支持创新方法的开发，特别是支持TTR核心。研究设计。流行病学，生物统计学和临床研究伦理/监管知识和支持（DBE/RKS）：提供综合的，以药物为重点的资源，以确保研究质量和在研究的所有阶段保护人类受试者。翻译技术和资源（TTR）支持15个核心功能的多样化组。跟踪和评估（TE）：CTSI-CN活动将由一个深思熟虑的详细评估计划指导和修改。相关性（见说明）：CTSI-CN提供高度集成、成本效益高、以调查者为中心的资源，旨在克服调查障碍，促进合作研究，并不断监测和评估，以确定何时需要进一步调整或修改。CTSI-CN位于国家首都，为受健康差异影响不成比例的儿童和家庭提供服务，它利用独特的资源将发现转化为改善健康，特别是在我们最弱势的儿童群体中。