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Combination Clostridium Difficile Toxin and Adhesin Vaccine

Combination Clostridium Difficile Toxin and Adhesin Vaccine
艰难梭菌毒素和粘附素联合疫苗
批准号：
8337121
负责人：
DAVID D HO
金额：
$74.15万
依托单位：
AARON DIAMOND AIDS RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-09-30 至 2012-06-30
来源：
https://reporter.nih.gov/project-details/8337121
关键词：
Active ImmunizationAddressAdherenceAdhesionsAdjuvantAgeAgingAnimal ModelAntibioticsAntibodiesAntibody FormationAntigensBacillus (bacterium)BacteriaBacterial AdhesinsBacterial InfectionsBindingBostonChimeric ProteinsClinicalClinical DataClostridium difficileColitisCombined VaccinesCommunicable DiseasesComorbidityDevelopmentDiarrheaDiseaseDisease ProgressionElderlyEnteralEnvironmental PollutionEpithelial CellsEuropeEvaluationExhibitsFamilyFlagellaFlagellinHamstersHandHeatingHospitalizationHospitalsHumanHygieneImmune responseImmunityImmunizationImmunoglobulin GIn VitroIncidenceIndividualInfectionInfection preventionInjuryIntestinesLaboratoriesLigandsMeasuresMediatingMesocricetus auratusModelingMusNew YorkOrganismOutcomePassive ImmunizationPatient IsolationPatientsPattern recognition receptorPlayPopulationPreventionPreventiveProductionProteinsReceptor SignalingRecombinant Fusion ProteinsRecombinantsRecurrenceRecurrent diseaseRegimenReportingReproduction sporesRiskRoleRouteSamplingSerumSurfaceSymptomsTestingToll-Like Receptor 5Toll-like receptorsToxinUnited StatesVaccinatedVaccinationVaccinesVirulence FactorsVirusadaptive immunitybasedesigndesign and constructionenterotoxin LTexperiencefliC gene productfungusimmunogenicimmunogenicityin vivomortalityneutralizing antibodynovelpathogenpreclinical studypreventprotective efficacyreceptor bindingresponsesuccesstherapeutic vaccinevaccine candidatevaccine efficacy

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