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Quantifying Effector Functions of Anti-HIV IgG1 Antibodies In Vivo.

体内量化抗 HIV IgG1 抗体的效应器功能。

基本信息

批准号：
10239076
负责人：
DAVID D HO
金额：
$ 24.77万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10239076
关键词：
Address Animals Antibodies Antibody Response Antibody Therapy Antigen Presentation Antiviral Agents Applications Grants Area Binding Blood CD4 Positive T Lymphocytes Cells Complement-Dependent Cytotoxicity Complex Data Data Set Death Rate Disease Ensure Equation Fc Receptor HIV HIV Antibodies HIV Infections HIV vaccine Half-Life Human IgG Receptors IgG1 Immunoglobulin G Immunology In Vitro Infection Knowledge Macaca mulatta Mathematics Measures Mediating Monkeys Mus NIH Program Announcements Patients Persons Plasma Property Series Specific qualifier value Vaccine Design Vaccines Viral Viral Antibodies Viral Load result Viremia Virion Virus Virus Diseases antibody-dependent cell cytotoxicity antibody-dependent cellular phagocytosis antiretroviral therapy comparative expectation experimental study humanized mouse improved in vivo insight mathematical analysis mouse model neutralizing antibody particle response simian human immunodeficiency virus vaccine discovery vaccine-induced antibodies viral RNA ward

项目摘要

PROJECT SUMMARY/ABSTRACT There is an abundance of evidence demonstrating the importance of Fc-mediated effector function to the overall activity of an antibody in vivo. However, the relative contribution of virus neutralization versus effector functions to the antiviral effect of an antibody remains undefined. We have proposed a series of experiments that will quantify the contributions of Fc-mediated effector functions to the overall activity of an antibody. The quantitative experiments will be performed in the setting of antibody treatment of SHIV infection in rhesus macaques. These fundamental questions in immunology have yet to be answered, and the resultant information promises to provide important insights on how the two major properties (neutralization versus effector functions) of a vaccine- induced IgG response combine forces to ward off the establishment of HIV infection.

项目总结/摘要有大量证据表明Fc介导的效应子功能对整体免疫应答的重要性。抗体在体内的活性。然而，病毒中和与效应功能的相对贡献抗体的抗病毒作用仍然不确定。我们提出了一系列的实验，量化Fc介导的效应子功能对抗体总体活性的贡献。定量实验将在恒河猴中SHIV感染的抗体治疗的背景下进行。这些免疫学中的基本问题尚未得到解答，由此产生的信息有望提供了关于疫苗的两个主要特性（中和与效应功能）的重要见解- 诱导的IgG反应联合收割机力量来抵御HIV感染的建立。