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Mechanisms of Brd2 immunoprotection from insulin resistance

Mechanisms of Brd2 immunoprotection from insulin resistance
Brd2 免疫保护胰岛素抵抗的机制
批准号：
8332905
负责人：
Gerald V Denis
金额：
$5.41万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-09-30 至 2013-08-31
来源：
https://reporter.nih.gov/project-details/8332905
关键词：
2,4-thiazolidinedioneAbdomenAblationAccelerationAdipocytesAdipose tissueAdultAgonistAnimal ModelAnimalsAnti-Inflammatory AgentsAnti-inflammatoryAttenuatedBindingBody WeightBone MarrowBromodomainCardiovascular DiseasesCell CycleCellsChronicCoculture TechniquesComorbidityDataDeveloped CountriesDevelopmentDiabetes MellitusDietDiseaseDominant-Negative MutationDrug effect disorderEtiologyFatty acid glycerol estersGene Expression ProfilingGeneral PopulationGenesGenetic TranscriptionGlucoseGreen Fluorescent ProteinsHealthHematopoietic stem cellsHumanIndividualInfiltrationInflammationInflammatoryInflammatory InfiltrateInflammatory ResponseInsulinInsulin ResistanceInterventionLearningLeukocytesLifeLinkLiver diseasesMalignant NeoplasmsMeasuresMediatingMetabolic syndromeModelingMolecularMorbid ObesityMusMutationNatureNeuropathyNon-Insulin-Dependent Diabetes MellitusObesityOverweightPPAR gammaPathway interactionsPatientsPhenotypePhysical activityPrevalenceProcessProductionProteinsPublic HealthPublishingRecruitment ActivityReducing dietReportingResearchRiskRoleSerum MarkersSignal Transduction PathwayStructureSystemT-LymphocyteTechniquesTertiary Protein StructureTestingTherapeuticThiazolidinedionesTimeTissuesTransactivationTumor Necrosis Factor-alphaWild Type MouseWorld Health Organizationbaseblood glucose regulationcancer typecardiovascular disorder riskcohortcytokinehealth care deliveryhuman TNF proteininnovationinsightinsulin sensitizing drugsknock-downlipid biosynthesismacrophagemutantnephrotoxicitynon-alcoholic fatty livernovelnovel therapeuticsoverexpressionreconstitutionresponsetoll-like receptor 4

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期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Metabolic disease risk in children by salivary biomarker analysis.
DOI： 10.1371/journal.pone.0098799
发表时间： 2014
期刊： PloS one
影响因子： 3.7
作者： [Goodson JM, Kantarci A, Hartman ML, Denis GV, Stephens D, Hasturk H, Yaskell T, Vargas J, Wang X, Cugini M, Barake R, Alsmadi O, Al-Mutawa S, Ariga J, Soparkar P, Behbehani J, Behbehani K, Welty F]
通讯作者： Welty F
BET domain co-regulators in obesity, inflammation and cancer.
DOI： 10.1038/nrc3256
发表时间： 2012-06-22
期刊： Nature reviews. Cancer
影响因子： --
作者： []
通讯作者：
Multiscale analysis of metabolic inflammation as a driver of breast cancer
  • 批准号：
    10063646
  • 项目类别：
  • 资助金额：
    $59.35万
  • 财政年份：
    2020
  • 负责人：
    Gerald V Denis
  • 依托单位：
    BOSTON UNIVERSITY MEDICAL CAMPUS
Multiscale analysis of metabolic inflammation as a driver of breast cancer
  • 批准号：
    10473886
  • 项目类别：
  • 资助金额：
    $66.26万
  • 财政年份：
    2020
  • 负责人：
    Gerald V Denis
  • 依托单位：
    BOSTON UNIVERSITY MEDICAL CAMPUS
Multiscale analysis of metabolic inflammation as a driver of breast cancer
  • 批准号：
    10259753
  • 项目类别：
  • 资助金额：
    $56.1万
  • 财政年份：
    2020
  • 负责人：
    Gerald V Denis
  • 依托单位：
    BOSTON UNIVERSITY MEDICAL CAMPUS
Mechanisms of BET bromodomain metabolic reprogramming in triple negative breast cancer
  • 批准号：
    10217042
  • 项目类别：
  • 资助金额：
    $61.96万
  • 财政年份：
    2018
  • 负责人：
    Gerald V Denis
  • 依托单位：
    BOSTON UNIVERSITY MEDICAL CAMPUS
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