Mechanisms of Brd2 immunoprotection from insulin resistance

Brd2 免疫保护胰岛素抵抗的机制

• 批准号: 8332905
• 负责人: Gerald V Denis
• 金额: $ 5.41万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8332905
• 关键词: 2,4-thiazolidinedione; Abdomen; Ablation; Acceleration; Adipocytes; Adipose tissue; Adult; Agonist; Animal Model; Animals; Anti-Inflammatory Agents; Anti-inflammatory; Attenuated; Binding; Body Weight; Bone Marrow; Bromodomain; Cardiovascular Diseases; Cell Cycle; Cells; Chronic; Coculture Techniques; Comorbidity; Data; Developed Countries; Development; Diabetes Mellitus; Diet; Disease; Dominant-Negative Mutation; Drug effect disorder; Etiology; Fatty acid glycerol esters; Gene Expression Profiling; General Population; Genes; Genetic Transcription; Glucose; Green Fluorescent Proteins; Health; Hematopoietic stem cells; Human; Individual; Infiltration; Inflammation; Inflammatory; Inflammatory Infiltrate; Inflammatory Response; Insulin; Insulin Resistance; Intervention; Learning; Leukocytes; Life; Link; Liver diseases; Malignant Neoplasms; Measures; Mediating; Metabolic syndrome; Modeling; Molecular; Morbid Obesity; Mus; Mutation; Nature; Neuropathy; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; PPAR gamma; Pathway interactions; Patients; Phenotype; Physical activity; Prevalence; Process; Production; Proteins; Public Health; Publishing; Recruitment Activity; Reducing diet; Reporting; Research; Risk; Role; Serum Markers; Signal Transduction Pathway; Structure; System; T-Lymphocyte; Techniques; Tertiary Protein Structure; Testing; Therapeutic; Thiazolidinediones; Time; Tissues; Transactivation; Tumor Necrosis Factor-alpha; Wild Type Mouse; World Health Organization; base; blood glucose regulation; cancer type; cardiovascular disorder risk; cohort; cytokine; health care delivery; human TNF protein; innovation; insight; insulin sensitizing drugs; knock-down; lipid biosynthesis; macrophage; mutant; nephrotoxicity; non-alcoholic fatty liver; novel; novel therapeutics; overexpression; reconstitution; response; toll-like receptor 4

项目成果

Metabolic disease risk in children by salivary biomarker analysis.

• DOI: 10.1371/journal.pone.0098799
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Goodson JM;Kantarci A;Hartman ML;Denis GV;Stephens D;Hasturk H;Yaskell T;Vargas J;Wang X;Cugini M;Barake R;Alsmadi O;Al-Mutawa S;Ariga J;Soparkar P;Behbehani J;Behbehani K;Welty F
• 通讯作者: Welty F

BET domain co-regulators in obesity, inflammation and cancer.

• DOI: 10.1038/nrc3256
• 发表时间: 2012-06-22
• 期刊: Nature reviews. Cancer