Using a multi-touch screen to automate pain assesment

使用多点触摸屏自动进行疼痛评估

• 批准号: 8200003
• 负责人: Jesse Brodkin
• 金额: $ 14.8万
• 依托单位: BEHAVIORAL INSTRUMENTS, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8200003
• 关键词: Acceleration; Affect; Algorithms; Analgesics; Animal Experimentation; Animal Testing; Animals; Area; Behavior; Behavioral; Biological Assay; Biology; Computer software; Computers; Data; Development; Devices; Failure; Formalin; Healthcare Systems; Human; Legal patent; Measures; Modeling; Movement; Mus; Pain; Pain Research; Pattern Recognition; Performance; Pharmacology; Process; Publications; Quality of life; Rattus; Reading; Recruitment Activity; Reporting; Research; Resolution; Rodent; Running; Sensitivity and Specificity; Solutions; Surface; System; Tablets; Techniques; Technology; Testing; Therapeutic; Touch sensation; Video Recording; Weight-Bearing state; base; behavior measurement; behavior test; chronic pain; commercialization; cost; design; experience; high throughput screening; innovation; input device; instrument; interest; pain behavior; phase 2 study; pre-clinical; response; sensor; software development; tool; touchscreen; user-friendly

DESCRIPTION (provided by applicant): Chronic pain is a major problem that significantly affects the quality of life of millions and costs our health care system billions of dollars annually. Despite major advances in our understanding of the biology and pharmacology of pain few new therapies have emerged. One significant factor contributing to this failure is the lack of a high- throughput assay to assess pain therapeutics in rodents. In this application we propose to automate and validate a high-throughput instrument to evaluate chronic pain in rats. The instruments we propose will be based on the recently introduced technology of multi- touch input devices as well as accelerometers. We will develop software to automate the scoring of historically validated behaviors which spontaneously occur in the widely used formalin pain test. This software will be validated by comparison to data obtained by an expert human observer. The product we envision is a validated, automated, user-friendly, high-throughput chronic pain testing device. We are particularly well suited to carry out this development as we have recruited top experts in the pain and pattern recognition fields, have a great deal of experience building accelerometers and animal testing instruments and have a patent pending on the use of multi-touch devices for behavioral testing (#61416417). PUBLIC HEALTH RELEVANCE: Assessing the effect of pain and analgesics in rats is a slow and costly process that creates a bottleneck in preclinical pain research. Successful development of the proposed system would alleviate this bottleneck by creating a rapid, automated and sensitive means to obtain a behavioral measure of pain in rats. This tool would advance research interests across many areas of chronic pain research.

描述(由申请人提供)： 慢性疼痛是一个重大问题，它严重影响数百万人的生活质量，并每年花费我们的医疗保健系统数十亿美元。尽管我们对疼痛的生物学和药理学的理解取得了重大进展，但几乎没有出现新的治疗方法。导致这一失败的一个重要因素是缺乏评估啮齿动物疼痛疗法的高通量测试。在这项应用中，我们建议自动化和验证高通量仪器来评估大鼠的慢性疼痛。我们建议的仪器将基于最近推出的多点触摸输入设备和加速计技术。我们将开发软件，对广泛使用的福尔马林疼痛测试中自发发生的历史验证行为进行自动评分。该软件将通过与专家人类观察者获得的数据进行比较来验证。我们设想的产品是一种经过验证的、自动化的、用户友好的、高通量的慢性疼痛测试设备。我们特别适合进行这一开发，因为我们已经招募了疼痛和模式识别领域的顶级专家，在制造加速计和动物测试仪器方面拥有丰富的经验，并且正在申请使用多点触摸设备进行行为测试的专利(#61416417)。 公共卫生相关性： 评估疼痛和止痛药对大鼠的影响是一个缓慢而昂贵的过程，这给临床前疼痛研究带来了瓶颈。拟议中的系统的成功开发将通过创建一种快速、自动化和灵敏的方法来获得大鼠疼痛的行为测量，从而缓解这一瓶颈。这一工具将促进慢性疼痛研究的许多领域的研究兴趣。