Defining the role of a novel E3 ubiquitin ligase in V(D)J recombination
Defining the role of a novel E3 ubiquitin ligase in V(D)J recombination
批准号:
8313160
负责人:
Patrick C. Swanson
金额:
$36.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-08-16 至 2013-07-31
关键词:
AccountingAddressAffectAnimal ModelAntigen ReceptorsB-Cell DevelopmentB-Cell LymphomasB-LymphocytesBenignBiochemicalCell LineCellular AssayChromosomal RearrangementChromosomal translocationCleaved cellCodeComplexCullin ProteinsDNADNA Repair PathwayDNA Sequence RearrangementDataDefectDevelopmentEventExhibitsFoundationsG22P1 geneGene RearrangementGene TargetingGenetic RecombinationGoalsHealthHumanImmune systemImmunodeficiency and CancerImmunologic Deficiency SyndromesKnowledgeLaboratoriesLengthLinkLymphocyteMalignant lymphoid neoplasmMapsMediatingModificationMolecular ProfilingMutationNonhomologous DNA End JoiningOutcomePathway interactionsPeptide Signal SequencesPhasePlayPopulation HeterogeneityProcessProtein BindingProteinsReceptor GeneRecurrenceResearchRoleSevere Combined ImmunodeficiencySite-Directed MutagenesisSurfaceSurface AntigensSyndromeT-Cell LeukemiaT-LymphocyteTestingUbiquitinUbiquitinationUrsidae FamilyV(D)J RecombinationWorkXRCC5 geneadaptive immunitybasecellular targetingfunctional lossimprovedleukemia/lymphomamicroorganismnovelreceptorrepairedubiquitin-protein ligase
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海外基金