课题基金 / 基金详情

Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin

Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin
颗粒体蛋白前体对 IL-10 基因表达和宿主败血症反应的调节
批准号：
8310364
负责人：
XIAOJING MA
金额：
$25.35万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-08-15 至 2013-07-31
来源：
https://reporter.nih.gov/project-details/8310364
关键词：
AddressAffectAnti-Inflammatory AgentsAnti-inflammatoryBacteriaBindingBone MarrowBrainCCL2 geneClinicalDependencyDevelopmentDiseaseElastasesEndotoxemiaEndotoxinsEquilibriumFoundationsGene ExpressionGenesGenetic TranscriptionGlycoproteinsGoalsHematopoiesisHomeostasisHost DefenseHumanIL10 geneImmuneImmune ToleranceImmune responseIn VitroInfectionInflammationInflammatoryInflammatory ResponseInterleukin-10Interleukin-12Interleukin-6InterventionKnock-outKnockout MiceLeadLigationLiquid substanceListeria monocytogenesLiverLuciferasesMediatingMicrobeModificationMolecularMusNatural ImmunityPeptidesPlayPositioning AttributePredispositionProductionProgranulinProteinsPuncture procedureRecombinantsRegulationReporterRespiratory BurstRoleSepsisSepsis SyndromeSeptic ShockSeriesSerine Proteinase InhibitorsSpleenStimulusTNF geneTestingTissuesTransgenesTraumaWound Healingactivating transcription factorantileukoproteaseantimicrobialchromatin remodelingchymotrypsincytokineeffective interventiongranulinhistone modificationhuman SLPI proteinin vivoinsightmacrophagemicrobialmonocyteneutrophilnovelnovel strategiespromoterresponseseptictranscription factor

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