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Mechanisms of Haemophilus influenzae pathogenesis in the lung

Mechanisms of Haemophilus influenzae pathogenesis in the lung
流感嗜血杆菌肺部发病机制
批准号：
8292726
负责人：
Brian Akerley
金额：
$42.4万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-07-15 至 2012-01-31
来源：
https://reporter.nih.gov/project-details/8292726
关键词：
AffectAnabolismAnti-Bacterial AgentsAntigensAreaBacteremiaBacteriaBacterial GenesBacterial PhysiologyBacterial PneumoniaBiological ModelsBlood CirculationClinicalComplementComplement Factor HDataDefectDevelopmentDiseaseEnvironmentGenesGenomeGlycosyltransferase GeneGrowthHaemophilus influenza virulenceHaemophilus influenzaeHost DefenseHumanImmuneImmune responseIncidenceIndividualInfectionInfluenza A virusInvadedLactamaseLungLung diseasesMeasuresMeningitisMetabolic PathwayModelingMolecularMonobactamsMusNasopharynxNatural ImmunityNontypable Haemophilus influenzaNoseOtitis MediaPathogenesisPathway interactionsPhagocytesPhysiologicalPhysiological AdaptationPneumoniaPrevalenceRespiratory SystemRespiratory tract structureRoleSerotypingSiteStructural GenesSymptomsTechniquesTherapeuticVaccinesViralVirulenceVirulence FactorsVirus DiseasesWorkabstractingbactericidebasecapsuleclinically relevantcombatconjunctivadesignfitnessin vitro Modelinfluenzavirusinsightlipooligosaccharidemicrobial hostmiddle earmortalitymutantneutrophilpathogenrespiratorysecondary infection

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期刊论文(2)
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科研奖励(0)
会议论文
Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae.
DOI： 10.3389/fcimb.2016.00040
发表时间： 2016
期刊： Frontiers in cellular and infection microbiology
影响因子： 5.7
作者： [Wong SM, Shaughnessy J, Ram S, Akerley BJ]
通讯作者： Akerley BJ
No-Go Zones for Mariner Transposition.
DOI： 10.1128/mbio.01690-16
发表时间： 2016-10-11
期刊： mBio
影响因子： 6.4
作者： [Akerley BJ]
通讯作者： Akerley BJ
Mechanisms underlying adhesion and colonization in pneumococcal keratitis
Targeted delivery of novel miRNA-based therapeutics for pneumonia-induced acute lung injury
  • 批准号：
    10700810
  • 项目类别：
  • 资助金额：
    $28.62万
  • 财政年份：
    2022
  • 负责人：
    Brian Akerley
  • 依托单位：
    ADVAC THERAPEUTIC, LLC
Targeted delivery of novel miRNA-based therapeutics for pneumonia-induced acute lung injury
  • 批准号：
    10395376
  • 项目类别：
  • 资助金额：
    $29.69万
  • 财政年份：
    2022
  • 负责人：
    Brian Akerley
  • 依托单位：
    ADVAC THERAPEUTIC, LLC
HEMOGLOBIN-INDUCED VIRULENCE IN STREPTOCOCCUSPNEUMONIAE
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