Mechanisms of Haemophilus influenzae pathogenesis in the lung

流感嗜血杆菌肺部发病机制

• 批准号: 8292726
• 负责人: Brian Akerley
• 金额: $ 42.4万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8292726
• 关键词: Affect; Anabolism; Anti-Bacterial Agents; Antigens; Area; Bacteremia; Bacteria; Bacterial Genes; Bacterial Physiology; Bacterial Pneumonia; Biological Models; Blood Circulation; Clinical; Complement; Complement Factor H; Data; Defect; Development; Disease; Environment; Genes; Genome; Glycosyltransferase Gene; Growth; Haemophilus influenza virulence; Haemophilus influenzae; Host Defense; Human; Immune; Immune response; Incidence; Individual; Infection; Influenza A virus; Invaded; Lactamase; Lung; Lung diseases; Measures; Meningitis; Metabolic Pathway; Modeling; Molecular; Monobactams; Mus; Nasopharynx; Natural Immunity; Nontypable Haemophilus influenza; Nose; Otitis Media; Pathogenesis; Pathway interactions; Phagocytes; Physiological; Physiological Adaptation; Pneumonia; Prevalence; Respiratory System; Respiratory tract structure; Role; Serotyping; Site; Structural Genes; Symptoms; Techniques; Therapeutic; Vaccines; Viral; Virulence; Virulence Factors; Virus Diseases; Work; abstracting; bactericide; base; capsule; clinically relevant; combat; conjunctiva; design; fitness; in vitro Model; influenzavirus; insight; lipooligosaccharide; microbial host; middle ear; mortality; mutant; neutrophil; pathogen; respiratory; secondary infection

项目成果

Defining the Binding Region in Factor H to Develop a Therapeutic Factor H-Fc Fusion Protein against Non-Typeable Haemophilus influenzae.

• DOI: 10.3389/fcimb.2016.00040
• 发表时间: 2016
• 期刊: Frontiers in cellular and infection microbiology
• 影响因子: 5.7
• 作者: Wong SM;Shaughnessy J;Ram S;Akerley BJ
• 通讯作者: Akerley BJ

No-Go Zones for Mariner Transposition.

• DOI: 10.1128/mbio.01690-16
• 发表时间: 2016-10-11
• 期刊: mBio
• 影响因子: 6.4
• 作者: Akerley BJ