Antiviral properties of an oxidative host defense system of the airways

气道氧化宿主防御系统的抗病毒特性

• 批准号: 8277715
• 负责人: Mark R Ackermann
• 金额: $ 55.87万
• 依托单位: IOWA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277715
• 关键词: Acids; Address; Adenovirus Infections; Adenoviruses; Agonist; Amino Acids; Animal Model; Anions; Anti-Bacterial Agents; Antiviral Agents; Apical; Area; Bacteria; Binding; Biological Assay; Bolus Infusion; Cell Culture Techniques; Cell-Free System; Cells; Clinical Research; Computer Simulation; Dapsone; Data; Development; Disease; Drug Kinetics; Enzymes; Epithelial; Epithelium; Exhibits; Extracellular Space; Frequencies; Future; Generations; Gland; Host Defense; Host Defense Mechanism; Human; Hydrogen Peroxide; Immune; In Vitro; Infection; Influenza; Ingestion; Intake; Intervention; Iodides; Ions; Lesion; Life; Lung; Measures; Membrane Proteins; Messenger RNA; Modeling; Modification; Morbidity - disease rate; Mucosal Immunity; Natural Immunity; OSCN-; Oral; Oxidases; P2Y2 receptor; Peptides; Physiological; Prevention; Production; Property; Prophylactic treatment; Proteins; RNA Viruses; Radiolabeled; Reaction; Recombinants; Reporter; Respiratory System; Respiratory Tract Infections; Respiratory syncytial virus; Respiratory tract structure; Rodent; SARS coronavirus; Sampling; Serum; Severities; Severity of illness; Sheep; Side; Staging; Supplementation; Surface; System; Testing; Therapeutic; Thiocyanates; Viral; Viral Antigens; Viral Genome; Viral Physiology; Viral Proteins; Viral Respiratory Tract Infection; Virulence; Virus; Virus Diseases; Virus Inactivation; Virus Replication; airway epithelium; airway surface liquid; antimicrobial; base; cytotoxicity; expectation; human subject; hypothiocyanite; in vivo; inhibitor/antagonist; interest; intravenous administration; lactoperoxidase; microbial; microbicide; mortality; novel therapeutic intervention; pathogen; pharmacokinetic model; prevent; prophylactic; radiotracer; research study; respiratory; respiratory infection virus; respiratory virus; viral RNA; virucide

项目成果

Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in Vero cells.

• DOI: 10.3390/v5112881
• 发表时间: 2013-11-22
• 期刊: Viruses
• 作者: Derscheid RJ;van Geelen A;McGill JL;Gallup JM;Cihlar T;Sacco RE;Ackermann MR
• 通讯作者: Ackermann MR