NOVEL LINKAGES OF THE PEPTIDOGLYCAN LAYER: ADAPTATION & RESISTANCE TO B-LACTAMS

肽聚糖层的新颖联系：适应

• 批准号: 8275083
• 负责人: Gyanu Lamichhane
• 金额: $ 41万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8275083
• 关键词: AIDS/HIV problem; Affect; Amoxicillin; Anabolism; Anti-Bacterial Agents; Antibiotics; Bacillus (bacterium); Biochemical; Case Study; Cell Wall; Cessation of life; Clavulanate; Clinical; Communicable Diseases; Data; Development; Disease; Drug Combinations; Drug Delivery Systems; Drug resistance; Drug usage; Environment; Enzyme Inhibition; Enzymes; Extreme drug resistant tuberculosis; Gene Expression Profile; Genes; Goals; Growth; Human; Infection; Maintenance; Metabolism; Mission; Molecular; Molecular Structure; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Organism; Outcome; Pathway interactions; Patients; Peptides; Peptidoglycan; Peptidyltransferase; Pharmaceutical Preparations; Physiological; Physiology; Population; Property; Public Health; Recording of previous events; Research; Resistance; Role; Specificity; Staging; Structure; Testing; Treatment Protocols; Tuberculosis; United States National Institutes of Health; Virulence; Work; antimicrobial; attenuation; base; beta-Lactam Resistance; beta-Lactamase; beta-Lactams; crosslink; in vivo; inhibitor/antagonist; insight; killings; mutant; next generation; novel; pathogen; small molecule; transpeptidation

项目成果

Targeting the cell wall of Mycobacterium tuberculosis: structure and mechanism of L,D-transpeptidase 2.

• DOI: 10.1016/j.str.2012.09.016
• 发表时间: 2012-12-05
• 期刊: Structure (London, England : 1993)
• 作者: Erdemli SB;Gupta R;Bishai WR;Lamichhane G;Amzel LM;Bianchet MA
• 通讯作者: Bianchet MA

Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactams.

结核分枝杆菌的非经典转肽酶改变细胞大小、形态、胞质基质、蛋白质定位、毒力和对β-内酰胺的抵抗力。

• DOI: 10.1128/jb.01396-13
• 发表时间: 2014
• 期刊: Journal of bacteriology
• 影响因子: 3.2
• 作者: Schoonmaker,MaiaK;Bishai,WilliamR;Lamichhane,Gyanu
• 通讯作者: Lamichhane,Gyanu