NOVEL LINKAGES OF THE PEPTIDOGLYCAN LAYER: ADAPTATION & RESISTANCE TO B-LACTAMS
NOVEL LINKAGES OF THE PEPTIDOGLYCAN LAYER: ADAPTATION & RESISTANCE TO B-LACTAMS
批准号:
8275083
负责人:
Gyanu Lamichhane
金额:
$41.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-07-01 至 2012-06-30
关键词:
AIDS/HIV problemAffectAmoxicillinAnabolismAnti-Bacterial AgentsAntibioticsBacillus (bacterium)BiochemicalCase StudyCell WallCessation of lifeClavulanateClinicalCommunicable DiseasesDataDevelopmentDiseaseDrug CombinationsDrug Delivery SystemsDrug resistanceDrug usageEnvironmentEnzyme InhibitionEnzymesExtreme drug resistant tuberculosisGene Expression ProfileGenesGoalsGrowthHumanInfectionMaintenanceMetabolismMissionMolecularMolecular StructureMycobacterium tuberculosisNational Institute of Allergy and Infectious DiseaseOrganismOutcomePathway interactionsPatientsPeptidesPeptidoglycanPeptidyltransferasePharmaceutical PreparationsPhysiologicalPhysiologyPopulationPropertyPublic HealthRecording of previous eventsResearchResistanceRoleSpecificityStagingStructureTestingTreatment ProtocolsTuberculosisUnited States National Institutes of HealthVirulenceWorkantimicrobialattenuationbasebeta-Lactam Resistancebeta-Lactamasebeta-Lactamscrosslinkin vivoinhibitor/antagonistinsightkillingsmutantnext generationnovelpathogensmall moleculetranspeptidation
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1016/j.str.2012.09.016
发表时间:
2012-12-05
期刊:
Structure (London, England : 1993)
影响因子:
--
作者:
[Erdemli SB, Gupta R, Bishai WR, Lamichhane G, Amzel LM, Bianchet MA]
通讯作者:
Bianchet MA
Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactams.
结核分枝杆菌的非经典转肽酶改变细胞大小、形态、胞质基质、蛋白质定位、毒力和对β-内酰胺的抵抗力。
DOI:
10.1128/jb.01396-13
发表时间:
2014
期刊:
Journal of bacteriology
影响因子:
3.2
作者:
[Schoonmaker,MaiaK, Bishai,WilliamR, Lamichhane,Gyanu]
通讯作者:
Lamichhane,Gyanu
Reference strains of Mycobacteroides abscessus
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批准号:10381458
-
项目类别:
-
资助金额:$23.97万
-
财政年份:2021
-
负责人:Gyanu Lamichhane
-
依托单位:
A strategy for new regimens to treat pulmonary Mycobacteroides abscessus infection
-
批准号:10264104
-
项目类别:
-
资助金额:$40.19万
-
财政年份:2020
-
负责人:Gyanu Lamichhane
-
依托单位:
A strategy for new regimens to treat pulmonary Mycobacteroides abscessus infection
-
批准号:10683091
-
项目类别:
-
资助金额:$40.94万
-
财政年份:2020
-
负责人:Gyanu Lamichhane
-
依托单位:
Oral dual β-lactams to treat pulmonary M. abscessus disease
-
批准号:10206006
-
项目类别:
-
资助金额:$24.56万
-
财政年份:2020
-
负责人:Gyanu Lamichhane
-
依托单位:
Oral dual β-lactams to treat pulmonary M. abscessus disease
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批准号:10027940
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项目类别:
-
资助金额:$20.47万
-
财政年份:2020
-
负责人:Gyanu Lamichhane
-
依托单位:
A strategy for new regimens to treat pulmonary Mycobacteroides abscessus infection
-
批准号:10458704
-
项目类别:
-
资助金额:$45.87万
-
财政年份:2020
-
负责人:Gyanu Lamichhane
-
依托单位:
A strategy for new regimens to treat pulmonary Mycobacteroides abscessus infection
-
批准号:10096918
-
项目类别:
-
资助金额:$41.27万
-
财政年份:2020
-
负责人:Gyanu Lamichhane
-
依托单位:
A strategy to treat M. abscessus infections
-
批准号:9763935
-
项目类别:
-
资助金额:$20.47万
-
财政年份:2019
-
负责人:Gyanu Lamichhane
-
依托单位:
Towards a new regimen to treat mycobacterial infection in cystic fibrosis patients
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批准号:9016299
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项目类别:
-
资助金额:$20.25万
-
财政年份:2015
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负责人:Gyanu Lamichhane
-
依托单位:
Development of an Oral Carbapenem Drug for Treatment of Drug Resistant TB
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批准号:8703923
-
项目类别:
-
资助金额:$23.61万
-
财政年份:2014
-
负责人:Gyanu Lamichhane
-
依托单位:
Development of an Oral Carbapenem Drug for Treatment of Drug Resistant TB
-
批准号:8800545
-
项目类别:
-
资助金额:$21.74万
-
财政年份:2014
-
负责人:Gyanu Lamichhane
-
依托单位:
New Drug for Treatment of Chronic Bacterial Infection
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批准号:8668380
-
项目类别:
-
资助金额:$20.0万
-
财政年份:2011
-
负责人:Gyanu Lamichhane
-
依托单位:
New Drug for Treatment of Chronic Bacterial Infection
-
批准号:8145918
-
项目类别:
-
资助金额:$243.0万
-
财政年份:2011
-
负责人:Gyanu Lamichhane
-
依托单位:
海外基金