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Production of Cross-Neutralizing HIV-1 Antibodies from Single B Cells

Production of Cross-Neutralizing HIV-1 Antibodies from Single B Cells
从单个 B 细胞生产交叉中和 HIV-1 抗体
批准号：
8262818
负责人：
MIROSLAW K GORNY
金额：
$76.32万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-06-01 至 2015-05-31
来源：
https://reporter.nih.gov/project-details/8262818
关键词：
AIDS/HIV problemAffinityAntibodiesAntibody FormationAntibody SpecificityAntigensB-LymphocytesBindingBiological AssayBlood specimenCameroonCellsCellular ImmunityCloningComplementary DNAComplexCrystallographyDevelopmentEpitope MappingEpitopesFc ImmunoglobulinsFlow CytometryFutureGenerationsGenesHIV vaccineHIV-1HumanHuman ActivitiesIgG1Immunoglobulin GImmunoglobulin GenesImmunoglobulinsImmunologyIndividualMapsMeasuresMediatingMemory B-LymphocyteMethodsModelingMolecularMonoclonal AntibodiesNaturePatientsPeptidesPeripheral Blood Mononuclear CellPlasmaProductionProteinsRecombinantsResistanceReverse Transcriptase Polymerase Chain ReactionRoleSamplingSerumSorting - Cell MovementSpecificitySpecimenStructureSurfaceTechniquesTestingTransfectionVaccine DesignVaccinesVariantViralVirusVirus DiseasesVirus-like particleWorkantibody-dependent cell cytotoxicitybasecohortdesignenv Gene Productsexpression vectorhuman monoclonal antibodiesimmunogenicimprovedinnovationmonoclonal antibody productionmutantneutralizing antibodyneutralizing monoclonal antibodiesnovelreceptortransfection/expression vectorvaccine candidatevolunteer

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