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Induction of HIV Neutralizing Antibodies by Targeting Macaque B Cell Receptors

Induction of HIV Neutralizing Antibodies by Targeting Macaque B Cell Receptors
通过靶向猕猴 B 细胞受体诱导 HIV 中和抗体
批准号：
8743681
负责人：
MIROSLAW K GORNY
金额：
$8.8万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
已结题
起止时间：
2013-12-19 至 2015-12-18
来源：
https://reporter.nih.gov/project-details/8743681
关键词：
3-DimensionalAffinityAnimalsAntibodiesAntigensAvidityB-LymphocytesBindingBinding SitesBlood specimenCell SeparationCellsChimeric ProteinsClinical TrialsComplementary DNACyclic PeptidesDNAEpitopesFlow CytometryGenesGoalsHIVHIV Envelope Protein gp120HIV vaccineHIV-1HumanImmune responseImmunizationImmunogeneticsImmunoglobulin GImmunoglobulin GenesImmunoglobulinsIndividualInfectionInhibitory Concentration 50MacacaMacaca mulattaMediatingMonitorMutationPeptidesPeripheral Blood Mononuclear CellProcessProductionProteinsReceptors, Antigen, B-CellRegimenRelative (related person)Reverse Transcriptase Polymerase Chain ReactionSerumShapesSomatic MutationSpecificitySpecimenStatistical MethodsTestingTimeVaccinesabstractingantigen bindingbasedesignenv Gene Productsexpression vectorgp160immunoglobulin receptorinnovationneutralizing antibodyneutralizing monoclonal antibodiesnovel strategiesreceptorvaccine development

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会议论文
Protective role of V2 antibodies induced at mucosal tissues in macaques
Monocional Antibody and Protein Core
Production of Cross-Neutralizing HIV-1 Antibodies from Single B Cells
Training Program on HIV Diversity and Drug Resistance-Enhancing Research Capacity
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