Automated Device for High Throughput Cell Cryopreservation

高通量细胞冷冻保存自动化设备

• 批准号: 8059022
• 负责人: John M BAUST
• 金额: $ 35.04万
• 依托单位: CELL PRESERVATION SERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8059022
• 关键词: Animals; Antibodies; Area; Atrial Fibrillation; Basic Science; Biocompatible Materials; Biological; Biological Preservation; Biological Products; Biological Sciences; Biomedical Engineering; Biosensor; Biotechnology; Cell Death; Cell Survival; Cell Therapy; Cell physiology; Cells; Cellular Stress; Coupling; Cryopreservation; Cryopreserved Cell; Cultured Cells; Data; Dental; Development; Device Designs; Devices; Diagnostic; Engineering; Fluorescence; Freezing; Goals; Growth; Hour; Human; Human Resources; Industry; Laboratories; Life; Link; Malignant Neoplasms; Medical; Molecular Biology; Monitor; Monoclonal Antibodies; Natural regeneration; Nitrogen; Pathway Analysis; Pathway interactions; Phase; Procedures; Process; Production; Proteins; Protocols documentation; Reader; Reproducibility; Research; Sampling; Science; Screening procedure; Solutions; Source; Stem Cell Research; Stress; System; Technology; Temperature; Testing; Therapeutic; Time; Time Management; Tissue Engineering; Tissues; Translational Research; Urethra; Vial device; Wound Healing; anticancer research; bioprocess; cell bank; cost; cost effective; design; drug discovery; experience; flexibility; gene therapy; hypothermosol; improved; innovation; instrument; interest; manufacturing process; new technology; novel; novel strategies; product development; prototype; response; scale up; stem cell therapy; technology development; theories; tool; user-friendly

DESCRIPTION (provided by applicant): The "cultured cell" has emerged as a critical link in the translation of research in the various fields of biotechnology and biomedicine. An unprecedented increase in the demand for cultured cell products is now driven by the growth in biopharmaceuticals, cancer research, cell and gene therapy and stem cell research. These industries now rely on dated, low-volume, non-standardized technologies to bank cells in the daily production of their critical cellular tool. CPSI Biotech is developing an innovative controlled rate freezing device, RapidCP", designed to rapidly freeze biological samples while maintaining sample quality and functionality. This Phase 1 proposal focuses on the development of an innovative research/ cell processing device, RapidCP" - a device designed to enable the high throughput freezing of samples for application in the bioprocessing, cell therapy, drug discovery, and basic sciences arena. Further, the design of the technology will allow for multiple independent cooling blocks thereby allowing for continuous processing of manageable lot sizes. This will reduce sample backlog, alleviate time constraints and allow more effective sample processing. This proposal represents an integrative approach to product development coupling engineering, and life sciences PUBLIC HEALTH RELEVANCE: This proposal is designed to develop a rapid cryopreservation device that more effectively cryopreserves cells than current instruments and protocols. A prototype device has already been developed and the preliminary data support the theory that such a device can be developed and be of interest to a variety of interested parties.

描述（由申请人提供）：“培养细胞”已成为生物技术和生物医学各个领域研究转化的关键环节。生物制药、癌症研究、细胞和基因治疗以及干细胞研究的增长推动了对培养细胞产品需求的空前增长。这些行业现在依赖于过时的、低容量的、非标准化的技术，在其关键细胞工具的日常生产中储存细胞。CPSI生物技术公司正在开发一种创新的控制速率冷冻设备，RapidCP”，旨在快速冷冻生物样品，同时保持样品的质量和功能。该第一阶段提案的重点是开发一种创新的研究/细胞处理设备“RapidCP”-一种旨在实现高通量冷冻样品的设备，用于生物处理、细胞治疗、药物发现和基础科学竞技场。此外，该技术的设计将允许多个独立的冷却块，从而允许连续处理可管理的批量大小。这将减少样品积压，缓解时间限制，并允许更有效的样品处理。该提案代表了产品开发耦合工程和生命科学的综合方法 公共卫生相关性：该提案旨在开发一种快速冷冻保存装置，该装置比当前的仪器和方案更有效地冷冻保存细胞。原型装置已经开发出来，初步数据支持这样一种理论，即可以开发这样一种装置，并引起各有关方面的兴趣。