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FrostBite - A Unique Catheter for Endoscopic Cryoablation

FrostBite - A Unique Catheter for Endoscopic Cryoablation
FrostBite - 用于内窥镜冷冻消融的独特导管
批准号:
8647726
负责人:
John M BAUST
金额:
$22.5万
依托单位国家:
美国
项目类别:
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-05-06 至 2016-02-29

项目摘要

项目成果

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中文摘要
翻译
迫切需要设计新的设备来促进范式变化的发展,
英文摘要
There is a pressing need for designing new devices facilitating the development of paradigm changing, minimally invasive, approaches to treat diseased tissues in situ. Additionally, there is a growing number of studies showing that combinatorial approaches are providing a path for personalization of strategies to treat a wide array of disease states. While providing a promising path to revolutionize medicine, the evolution of personalized, minimally invasive, combinatorial therapies has been slowed as a result of technological limitations. As such, there is a pressing need for new medical devices to enable the development of trans-disciplinary strategies to combat disease. This Phase 1 project is designed to address this need through the development of a new flexible endoscopic compatible catheter designed for the treatment of various gastrointestinal related tissue diseases enabling the application of multiple therapeutic and diagnostic approaches (pharmaceutical, dual-ablation, cell and gene therapy, among others) in a single device format (FrostBite). The ability to deliver multi- parametric treatment regimes of the FrostBite catheter is enhanced by its compatibility with advanced imaging approaches including endoscopic ultrasound, MRI, and CT. Initial R&D activities have resulted in a prototype 1.5mm needle tip catheter capable of delivering dual thermal insults to a target within 10 seconds creating a zone of destruction of ~2.5cm in less than 2 mins. Preliminary studies into combinatorial drug/thermal insults have shown improved outcomes in tissue models as well. Under this proposal we intend to develop and test this next generation endoscopic compatible catheter as well as evaluate a series of combinatorial strategies. Successful completion of this project will provide for a novel medical device enabling the development and application of advanced personalized treatment regimes for 100's of thousands of patients who suffer from numerous gastrointestinal tissue disease states which are untreatable or inadequately treated with today's state of the art devices.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Investigation of the Impact of Cell Cycle Stage on Freeze Response Sensitivity of Androgen-Insensitive Prostate Cancer.
细胞周期阶段对雄激素不敏感前列腺癌冷冻反应敏感性影响的研究。
DOI: 10.1177/1533034616648059
发表时间: 2016
期刊: Technology in cancer research & treatment
影响因子: 2.8
作者: [Santucci,KimberlyL, Baust,JohnM, Snyder,KristiK, VanBuskirk,RobertG, Baust,JohnG]
通讯作者: Baust,JohnG
FrostBite-DMR - A New Drug-Free Approach for Treating Type 2 Diabetes
  • 批准号:
    10596881
  • 项目类别:
  • 资助金额:
    $29.83万
  • 财政年份:
    2022
  • 负责人:
    John M BAUST
  • 依托单位:
FrostBite-DMR - A new Drug-Free Approach for Treating Type 2 Diabetes Supplemental Request
  • 批准号:
    10748325
  • 项目类别:
  • 资助金额:
    $1.21万
  • 财政年份:
    2022
  • 负责人:
    John M BAUST
  • 依托单位:
The SmartBio System for the Improved Preservation of Human Hematopoietic Stem Cells
The SmartBio System for the Improved Preservation of Human Hematopoietic Stem Cells
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