FrostBite - A Unique Catheter for Endoscopic Cryoablation

FrostBite - 用于内镜冷冻消融的独特导管

基本信息

  • 批准号:
    9984633
  • 负责人:
  • 金额:
    $ 0.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-05-06 至 2020-07-31
  • 项目状态:
    已结题

项目摘要

A growing number of studies have demonstrated that combinatorial approaches are providing a path for personalization of strategies to treat a wide array of disease states. While providing a promising path to revolutionize medicine, the evolution of personalized, minimally invasive, combinatorial therapies has been slowed as a result of technological limitations. As such, there is a pressing need for designing new devices to facilitate the development of paradigm changing, minimally invasive, approaches to treat diseased tissues in situ which enable trans-disciplinary strategies to combat disease. This Phase 2 project, which builds upon the success of the completed Phase 1, is designed to address this need through the development of a next generation flexible endoscopic compatible ablation catheter platform (FrostBite) for the treatment of various gastrointestinal cancers including pancreatic and liver cancer. This multi-functional platform will enable the application of multiple therapeutic and diagnostic approaches (pharmaceutical, ablation, among others) in a single device format which when combined with novel vitamin D3 analogs designed to increase the lethality of freezing, will provide for an enhanced treatment option for numerous cancers. The ability to deliver multi-parametric treatment regimens of the FrostBite catheter is enhanced by the incorporation of a novel deployable thermosensor to monitor ablation zone formation in real time. This, when combined with advanced imaging approach compatibility, including endoscopic ultrasound, MRI, and CT, will provide for unmatched control and visualization during a procedure. Phase 1 activities yielded a prototype 1.27mm needle tip catheter capable of delivering cryothermal insults to a target within 10 seconds creating a zone of destruction of ~2.5cm in less than 3 mins. Studies into combinatorial drug/thermal insults also demonstrated improved outcomes in tissue models. This Phase 2 is designed to 1) miniaturize and test the next generation endoscopic compatible cryocatheter, 2) integrate a novel in situ deployable multipoint thermal sensor to enable real time monitoring of the thermal profile of the target during ablation, 3) develop and evaluate a series of vitamin D3 analogs (commercial and novel), and test the optimal combination device and analog protocol in an ex vivo engineered tumor model and in in vivo studies. This project builds upon successful P1 studies, as well as others, and leverages the combined expertise of researchers from CPSI, University of Ottawa, Binghamton University, and Johns Hopkins School of Medicine to develop a new surgical device and adjunctive drug combination approach to more effectively treat cancers of the liver and pancreas. Once completed, this project will provide for an effective, minimally invasive treatment option for individuals suffering from these and other gastroenterological based cancers such as colorectal, stomach and esophageal cancer. Successful completion of this project will provide for a novel medical device enabling the development and application of advanced personalized treatment regimes for 100’s of thousands of patients who suffer from numerous gastrointestinal tissue disease states which are untreatable or inadequately treated with today’s state of the art devices yielding improved patient survival and quality of life.
越来越多的研究表明,组合方法正在为 个性化治疗多种疾病状态的策略。同时提供了一条很有希望的途径 革命性的医学,个性化,微创,组合疗法的发展 由于技术的限制而变慢了。因此,迫切需要设计 促进改变范式的新设备的开发,最小限度地侵袭,方法 就地治疗病变组织,从而能够采取跨学科的策略与疾病作斗争。这一阶段 建立在已完成的第一阶段成功的基础上的2个项目就是为了满足这一需求 通过开发下一代柔性内窥镜兼容消融导管平台 (冻伤)用于治疗各种胃肠道癌症,包括胰腺癌和肝癌。 这一多功能平台将使多种治疗和诊断的应用成为可能 单一设备格式的方法(药物、消融等),当组合在一起时 新型维生素D3类似物旨在增加冷冻的致命性,将提供 增强了多种癌症的治疗选择。提供多参数治疗的能力 通过加入一种新型的可展开的导管来改进冻伤导管的治疗方案 用于实时监测消融区形成的温度传感器。这一点与先进的 成像方法的兼容性,包括内窥镜超声、核磁共振和CT,将提供 在一个过程中无与伦比的控制和可视化。第一阶段的活动产生了1.27 mm的原型 针尖导管能够在10秒内将低温损伤传递到目标,从而产生 在不到3分钟的时间里破坏了~2.5厘米的区域。联合用药/热损伤的研究 在组织模型中证明了改善的结果。此阶段2旨在1)小型化和测试 下一代内窥镜兼容低温测量仪,2)集成了一种新型的可原位展开的 多点热传感器,能够实时监测目标的热轮廓 消融,3)开发和评估一系列维生素D3类似物(商业和新型),并测试 体外和体内工程肿瘤模型中的最佳组合装置和模拟方案 学习。该项目建立在成功的P1研究以及其他研究的基础上,并利用 CPSI、渥太华大学、宾厄姆顿大学和约翰霍普金斯大学的研究人员的专业知识 医学院将开发一种新的手术器械和辅助药物组合方法 更有效地治疗肝癌和胰腺癌。一旦完成,该项目将提供 对于患有这些和其他疾病的个人来说,一种有效的微创治疗选择 以胃肠病为基础的癌症,如结直肠癌、胃癌和食道癌。成功 该项目的完成将提供一种新的医疗设备,使开发和 应用先进的个体化治疗方案治疗上千例S患者 从许多无法治疗或治疗不充分的胃肠道组织疾病状态 当今最先进的设备提高了患者的存活率和生活质量。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
An In Vitro Investigation into Cryoablation and Adjunctive Cryoablation/Chemotherapy Combination Therapy for the Treatment of Pancreatic Cancer Using the PANC-1 Cell Line.
  • DOI:
    10.3390/biomedicines10020450
  • 发表时间:
    2022-02-15
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Baust JM;Santucci KL;Van Buskirk RG;Raijman I;Fisher WE;Baust JG;Snyder KK
  • 通讯作者:
    Snyder KK
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John M BAUST其他文献

John M BAUST的其他文献

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{{ truncateString('John M BAUST', 18)}}的其他基金

FrostBite-DMR - A new Drug-Free Approach for Treating Type 2 Diabetes Supplemental Request
FrostBite-DMR - 一种治疗 2 型糖尿病的新无药方法补充请求
  • 批准号:
    10748325
  • 财政年份:
    2022
  • 资助金额:
    $ 0.18万
  • 项目类别:
FrostBite-DMR - A New Drug-Free Approach for Treating Type 2 Diabetes
FrostBite-DMR——一种治疗 2 型糖尿病的无药物新方法
  • 批准号:
    10596881
  • 财政年份:
    2022
  • 资助金额:
    $ 0.18万
  • 项目类别:
The SmartBio System for the Improved Preservation of Human Hematopoietic Stem Cells
用于改善人类造血干细胞保存的 SmartBio 系统
  • 批准号:
    9228432
  • 财政年份:
    2016
  • 资助金额:
    $ 0.18万
  • 项目类别:
The SmartBio System for the Improved Preservation of Human Hematopoietic Stem Cells
用于改善人类造血干细胞保存的 SmartBio 系统
  • 批准号:
    9925574
  • 财政年份:
    2016
  • 资助金额:
    $ 0.18万
  • 项目类别:
FrostBite - A Unique Catheter for Endoscopic Cryoablation
FrostBite - 用于内窥镜冷冻消融的独特导管
  • 批准号:
    8647726
  • 财政年份:
    2014
  • 资助金额:
    $ 0.18万
  • 项目类别:
Enhanced Bioprocessing Strategies for Human Mesenchymal Stem Cells
人类间充质干细胞的增强生物加工策略
  • 批准号:
    8096921
  • 财政年份:
    2011
  • 资助金额:
    $ 0.18万
  • 项目类别:
Automated Device for High Throughput Cell Cryopreservation
高通量细胞冷冻保存自动化设备
  • 批准号:
    8059022
  • 财政年份:
    2011
  • 资助金额:
    $ 0.18万
  • 项目类别:
CellGuard - A Novel Approach for Protecting Cells During Bioprocessing
CellGuard - 生物加工过程中保护细胞的新方法
  • 批准号:
    7940083
  • 财政年份:
    2009
  • 资助金额:
    $ 0.18万
  • 项目类别:
CellGuard - A Novel Approach for Protecting Cells During Bioprocessing
CellGuard - 生物加工过程中保护细胞的新方法
  • 批准号:
    7671200
  • 财政年份:
    2009
  • 资助金额:
    $ 0.18万
  • 项目类别:
Development of an In Situ Anhydrobiotic Tissue Culture Process
原位脱水组织培养工艺的开发
  • 批准号:
    7481983
  • 财政年份:
    2008
  • 资助金额:
    $ 0.18万
  • 项目类别:

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