X8 Prospector for Macromolecular Crystallography

X8 Prospector 用于高分子晶体学

• 批准号: 8051413
• 负责人: THOMAS D. HURLEY
• 金额: $ 45.33万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8051413
• 关键词: 16 year old; Aging; Alcoholism; Anodes; Biochemistry; Cardiovascular Diseases; Crystallography; Diabetes Mellitus; Disease; Environment; Faculty; Foundations; Foxes; Funding; Grant; HRH2 gene; Health; Indiana; Lead; Malignant Neoplasms; Molecular Biology; Molecular Structure; Neurodegenerative Disorders; Play; Proteins; Request for Applications; Research; Research Personnel; Research Support; Role; System; Therapeutic; United States National Institutes of Health; Universities; X-Ray Crystallography; drug discovery; improved; instrumentation; macromolecule; medical schools; member; tool

DESCRIPTION (provided by applicant): This S10 application requests funds for a Bruker X8 Prospector integrated diffraction system along with an Oxford cryostream to replace the aging system within the Department of Biochemistry and Molecular Biology at the Indiana University School of Medicine. The user group consists of 6 major users, 4 of whom are NIH funded investigators with 10 active grants and an additional 5 pending NIH grants. In addition, two new outstanding new faculty members with national-level funding from AHA and NSF, as well as the Michael J. Fox Foundation are part of the user group. X-ray crystallography is a powerful tool for the study of macromolecular structure. The research supported by this instrumentation request will lead to a better understanding of the roles our target proteins play in health and disease. Many of our major users are also involved in drug discovery research, which may ultimately lead to improved therapeutic approaches to treat diseases such as alcoholism, cardiovascular disease, diabetes, neurodegenerative disorders and cancer. The new instrumentation will be integrated into our existing X- ray crystallography facility by replacing the over 16 year-old H2R rotating anode generator. The upgrade of our facilities will allow our productive research faculty to remain competitive in the NIH funding environment and will undoubtedly lead to new advances in our understanding of the function of biomedically relevant macromolecules. PUBLIC HEALTH RELEVANCE: X-ray crystallography is a powerful tool for the study of macromolecular structure. The research supported by this instrumentation request will lead to a better understanding of the roles our target proteins play in health and disease. Many of our major users are also involved in drug discovery research which may ultimately lead to improved therapeutic approaches for diseases such as alcoholism, cardiovascular disease, diabetes and cancer.

描述(由申请人提供)：这份S10申请申请资金用于布鲁克X8 Prospector集成衍射系统和牛津冷冻流，以取代印第安纳大学医学院生物化学和分子生物学系内的老化系统。用户组由6个主要用户组成，其中4个是NIH资助的调查人员，有10个正在进行的赠款和另外5个待批的NIH赠款。此外，由AHA和NSF以及迈克尔·J·福克斯基金会提供国家级资金的两名新的杰出新教师是用户组的一部分。X射线结晶学是研究大分子结构的有力工具。由这一仪器请求支持的研究将使我们更好地理解我们的目标蛋白在健康和疾病中所起的作用。我们的许多主要用户还参与了药物发现研究，这最终可能导致改进治疗方法，以治疗酒精中毒、心血管疾病、糖尿病、神经退行性疾病和癌症等疾病。新的仪器将被整合到我们现有的X射线结晶学设备中，取代已有16年历史的H2 R旋转阳极发生器。我们设施的升级将使我们富有成效的研究人员在NIH的资助环境中保持竞争力，并无疑将导致我们对生物医学相关大分子功能的理解取得新的进展。 与公众健康相关：X射线结晶学是研究大分子结构的有力工具。由这一仪器请求支持的研究将使我们更好地理解我们的目标蛋白在健康和疾病中所起的作用。我们的许多主要用户还参与了药物发现研究，最终可能会改进酒精中毒、心血管疾病、糖尿病和癌症等疾病的治疗方法。