Aperio ScanScope XT Digital Slide Scanner System

描述（由申请人提供）：肯塔基大学建议购买Aperio ScanScope(R) XT数字幻灯片扫描仪，包括ImageScope“/Genie”和Webscope“查看软件。该仪器将被安置在肯塔基大学阿尔茨海默病中心神经病理学核心实验室。地理位置安全可靠，但对所有主要和次要用户开放，具有出色的机构支持。11个主要用户和3个次要用户，代表大学内十个不同的学术部门，强烈希望使用该仪器。目前在肯塔基大学内部或附近没有类似的仪器；然而，这一科学进步与肯塔基大学现有的医学专业知识、技术基础设施和研究设施非常吻合。Aperio ScanScope XT以数字化格式扫描和分析显微镜载玻片，从而实现组织病理学数据的优化和详细存档和数据挖掘。该仪器通过促进ND组织病理学特征的数字化识别和分析，除了正常结构外，还代表了定量神经病理学领域的重要技术进步。此外，滑动扫描仪是理想的，用于改善立体学中存活细胞计数的定量测量，原位杂交信号量化，动物模型评估（包括脑外伤和朊病毒疾病模型），以及其他将直接促进美国国立卫生研究院资助的肯塔基大学主要用户的研究项目的前沿应用。该仪器将提供一个独特的机会来介绍、验证和发表用于量化脑病理学的数字显微镜和生物信息学方法。该文书将有一个基础广泛的咨询小组，由肯塔基大学八个不同的学术部门代表组成。最后，由于其基于网络的功能，购买Aperio ScanScope XT将允许在肯塔基州的偏远地区和通过全国阿尔茨海默病中心网络交换数据。

DESCRIPTION (provided by applicant): The University of Kentucky proposes to acquire an Aperio ScanScope(R) XT digital slide scanner including the ImageScope"/Genie" and Webscope" viewing software. This instrument will be housed in the University of Kentucky Alzheimer's Disease Center Neuropathology Core laboratory. The location is safe and secure, but open to all the Major and Minor Users, with outstanding Institutional Support. 11 Major Users and 3 Minor Users, representing ten different academic departments within the University, strongly desire the instrument. There is no analogous instrument currently available within or nearby the University of Kentucky; however, this scientific advancement dovetails very well with existing medical expertise, technical infrastructure, and research facilities at the University of Kentucky. The Aperio ScanScope XT scans and analyzes microscope slides in a digitized format that will enable optimized and detailed archiving and data mining of histopathological data. The instrument represents a significant technological step forward for the field of quantitative neuropathology by facilitating the digitized identification and analysis of histopathological hallmarks of ND, in addition to normal structures. In addition, the slide scanner is ideal for improving quantitative measures of surviving cell counts in stereology, in situ hybridization signal quantification, animal model assessments (including brain trauma and prion disease models), and other cutting edge applications that will directly facilitate NIH-funded research projects by Major Users at the University of Kentucky. This instrument will provide a unique opportunity to introduce, validate, and publish methods in digital microscopy and bioinformatics for the purpose of quantifying brain pathology. The instrument will have an Advisory Panel that is broad-based, with representation by eight different academic departments from the University of Kentucky. Finally, due to its web-based functionality, the purchase of the Aperio ScanScope XT will allow for the exchange of data throughout Kentucky's remote regions and through the network of Alzheimer's Disease Centers nationally.