Core D: University of Kentucky Alzheimer's Disease Core Center

核心 D：肯塔基大学阿尔茨海默病核心中心

• 批准号: 10459469
• 负责人: PETER T. NELSON
• 金额: $ 28.01万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459469
• 关键词: Address; Aging; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Area; Autopsy; Biological; Biological Markers; Biological Specimen Banks; Biometry; Brain; Brain Diseases; Brain imaging; Brain region; Caring; Catalogs; Cerebrospinal Fluid; Cerebrovascular Disorders; Cerebrum; Clinical; Clinical Trials; Cognitive; Collaborations; Complement; Consensus; Correlation Studies; Correlative Study; DNA; Data; Databases; Dementia; Dementia with Lewy Bodies; Deposition; Diagnosis; Diagnostic; Disease; Down Syndrome; Elderly; Ensure; Etiology; Evaluation; Freezing; Frontotemporal Lobar Degenerations; Genetic study; Genomics; Goals; Impaired cognition; Individual; Infrastructure; Institutes; Investigation; Kentucky; Laboratory Research; Lesion; Medical Genetics; Memory; Methodology; Methods; Mission; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Pathologic; Pathology; Patients; Plasma; Preventive measure; Process; Protocols documentation; Publishing; Research; Research Personnel; Research Support; Resources; Running; Sampling; Senile Plaques; Serum; Services; Specimen; Staging; Standardization; Syndrome; System; Tauopathies; Therapeutic; Thinness; Time; Tissue Banks; Tissue Sample; Tissues; Universities; Work; age related; age related neurodegeneration; aging brain; alpha synuclein; blood product; brain tissue; cerebrovascular pathology; clinical biomarkers; cohort; data management; digital; digital pathology; early satiety; experience; genome wide association study; hippocampal sclerosis; innovation; limbic-predominant age-related TDP-43 encephalopathy; meetings; mixed dementia; neuroinflammation; neuropathology; novel; pre-clinical; protein TDP-43; religious order study; statistics; symposium; synucleinopathy; tau Proteins; tool

Project Summary/Abstract: Neuropathology Core The overall objective of the Neuropathology Core of the UK-ADRC is to support research on normal brain aging, presymptomatic AD, MCI, early and late AD, mixed dementia syndromes, and other dementing disorders. Autopsies will be performed by our Rapid Autopsy Team on longitudinally followed subjects from our Clinical Core. We will perform short post-mortem interval autopsies, and we will maintain a high autopsy rate. This Core is optimally tailored to help address important research questions. The Core will provide brain tissue, CSF and other biospecimens for investigators at UK, other ADRCs, and outside investigators. The Core will also provide consensus conference determined diagnoses, quantitation of neurofibrillary tangles, neuritic plaques, and diffuse plaques from 8 brain regions, Ab quantitation, Braak staging, CERAD, and NIA-Reagan Institute staging on all autopsied cases, along with evaluation of alpha-synuclein and TDP-43 proteinopathy. This brain bank has been operating continuously for over three decades with a strong track record, so special care will be taken to ensure diagnostic excellence, consistency, and continuity. The Core will maintain a tissue bank of the above specimens and frozen serum, plasma, buffy coats and CSF from living patients. Special emphasis will be placed on generating rigorous quantititative pathologic metrics from digital pathology, and providing investigators with specimens from cognitively intact control subjects with no Ab deposition and sparse tau pathology (successful cerebral aging) and many cases with mixed pathologies. Providing these samples will contribute to clinical-pathological correlation studies and cutting-edge research that include sponsored studies related to AD genomics, oxidative stress, hippocampal sclerosis/LATE, dementia with Lewy bodies, Down syndrome, and neuroinflammation. Frequent consensus conferences will be held with the Clinical, Biomarker, and Data Management and Statistics Cores to help define clinical-pathological diagnoses on all autopsied subjects. The Neuropathology Core is strongly integrated with other Cores of the UK-ADRC, and exploits unique opportunities to conduct clinical-pathological correlative studies on longitudinally followed subjects. Through these methods we will better understand normal brain aging and the transition to multi- etiology dementia with the goal of contributing to therapeutic or preventive measures. The Neuropathology Core complements the other Cores of the UK-ADRC to provide extremely essential diagnoses and tissue samples that are required for many cutting-edge researchers at the University of Kentucky and elsewhere. We will build on our track record of excellence using innovative tools related to brain autopsies, neuropathological diagnoses, tissue banking, and clinical-pathological correlation. Our specific aims are: Aim 1: Provide state-of-the-art neuropathological and biospecimen repository services Aim 2: Leverage neuropathology resources and expertise to contribute to research efforts Aim 3: Integrate with other cores to contribute to administrative, research and educational missions

项目摘要/摘要：神经病理学核心 英国 ADRC 神经病理学核心的总体目标是支持正常大脑的研究 衰老、症状前 AD、MCI、早期和晚期 AD、混合性痴呆综合征和其他痴呆 失调。尸检将由我们的快速尸检团队对来自我们的纵向跟踪对象进行 临床核心。我们将进行较短的尸检间隔，并保持较高的尸检率。 该核心经过优化定制，可帮助解决重要的研究问题。核心将提供脑组织， 为英国研究人员、其他 ADRC 和外部研究人员提供脑脊液和其他生物样本。核心将 还提供共识会议确定的诊断、神经原纤维缠结、神经炎的定量 来自 8 个脑区的斑块和弥漫性斑块、Ab 定量、Braak 分期、CERAD 和 NIA-Reagan 对所有尸检病例进行分期，并评估 α-突触核蛋白和 TDP-43 蛋白病。 这个脑库已经连续运行了三十多年，有着良好的记录，所以很特别 将注意确保诊断的卓越性、一致性和连续性。核心将维持组织 上述标本库以及来自活体患者的冷冻血清、血浆、血沉棕黄层和脑脊液。特别的 重点将放在从数字病理学中生成严格的定量病理指标，以及 为研究人员提供来自认知完整的对照受试者的样本，没有抗体沉积，并且 稀疏的 tau 蛋白病理学（成功的脑老化）和许多混合病理学病例。提供这些 样本将有助于临床病理相关性研究和前沿研究，包括 赞助与 AD 基因组学、氧化应激、海马硬化/晚期、路易痴呆相关的研究 身体、唐氏综合症和神经炎症。将与各方频繁召开共识会议 临床、生物标志物、数据管理和统计核心，帮助定义临床病理诊断 所有尸检对象。神经病理学核心与 UK-ADRC 的其他核心紧密结合， 并利用独特的机会对纵向随访进行临床病理相关研究 科目。通过这些方法，我们将更好地了解正常的大脑衰老和向多细胞的转变。 病因学痴呆，目的是促进治疗或预防措施。神经病理学 核心补充了 UK-ADRC 的其他核心，提供极其重要的诊断和组织 肯塔基大学和其他地方的许多尖端研究人员所需的样本。我们 将利用与脑尸检、神经病理学相关的创新工具来建立我们的卓越记录 诊断、组织库和临床病理相关性。我们的具体目标是： 目标 1：提供最先进的神经病理学和生物样本存储库服务 目标 2：利用神经病理学资源和专业知识为研究工作做出贡献 目标 3：与其他核心整合，为行政、研究和教育使命做出贡献