GENOMIC AND PROTEOMIC DETERMINANTS OF LOWER EXTREMITY REVASCULARIZATION FAILURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 拟议的人类研究计划利用了佛罗里达大学的几个优势，其中最重要的是炎症生物学和外科科学实验室，在功能基因组学和蛋白质组学应用于人类疾病方面具有公认的专业知识。 利用这些资源，该研究旨在验证以下假设：血管干预后的全身炎症反应影响负责血管修复和适应的局部环境。 预期这种反应在所有患者中并不一致，而是受到一些术前遗传易感性或单核细胞功能的差异围手术期调节的调节，这些调节将血管反应推向闭塞性适应不良表型。 早期干预失败与下肢缺血复发和对生活质量的负面影响是潜在的结果。 外周动脉闭塞性疾病是一个重要的国家医疗保健问题，通过这项工作获得的信息将产生新的策略来改善现有的下肢血运重建方法。 它还将在更广泛的范围内为外周血管疾病的全面管理提供新的知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed human research initiative takes advantage of several strengths at the University of Florida the most important of which is the Laboratory of Inflammation Biology and Surgical Science with recognized expertise in the application of functional genomics and proteomics to human disease. Using these resources, the study aims to test the hypothesis that the systemic inflammatory response following vascular intervention influences the local milieu responsible for vascular repair and adaptation. The expectation being that this response is not uniform in all patients, but rather, is modulated by either some preoperative genetic predisposition or differential periprocedural regulation of monocyte function that drives the vascular response towards an occlusive maladaptive phenotype. Early intervention failure with recurrent lower extremity ischemia and a negative impact on quality of life is the potential result. Peripheral arterial occlusive disease is a significant national health care concern and the information gained through this work will lead to new strategies to improve existing approaches to lower extremity revascularization. It will also provide new knowledge in the overall management of peripheral vascular disease on a significantly broader scope.