Translational Analyses of Chronic Aberrant Behavior Across the Life Span

描述(由申请人提供)：行为障碍，包括攻击性和自我伤害，可能会给智力和发育障碍(IDD)患者及其照顾者带来相当大的痛苦，并导致本已不堪重负的医疗保健系统显著增加成本。这类障碍在这里被称为慢性异常行为(CAB)，已经使用行为分析领域提供的程序进行了有效的治疗，这些程序基于对操作性学习原则的翻译研究。这项拟议的研究计划的目的是扩大IDD患者CAB治疗的概念基础和范围。这项拟议的研究计划值得注意的方面是，研究将由以研究和治疗CAB而闻名的研究人员进行，并在三个独立的卓越中心(即目前被公认为几十年来创新和杰出成就的领导者的三个iDDR中心)进行。随着计算机技术和电信技术的巨大进步，这种多地点研究的方法只是在过去几年才开始实用。因此，现在可以在匹配实验资源的基础上选择研究人员和地点。在三个研究中心和四个地点进行的调查将集中在：(1)检查激励变化在触发CAB和基于这一新概念框架的干预措施开发中的作用；(2)应用行为经济学原理来影响替代建设性活动而不是CAB的选择；以及(3)促进治疗成果在环境、人和环境中的推广。行政核心和方法廉正核心将支持拟议的研究。这种多部位、多方面的治疗IDD CAB的方法所产生的证据将使设计出更好的IDD患者治疗方案以过上更好的生活成为可能。

DESCRIPTION (provided by applicant): Behavior disorders, including aggression and self-injury, can cause considerable suffering for individuals with intellectual and developmental disabilities (IDD) and their care givers, as well as result in significant added costs to an already overburdened health care system. Such disorders, here termed Chronic Aberrant Behavior (CAB), have been effectively treated using procedures, provided by the field of Behavior Analysis, that are based on translational studies of operant learning principles. The purposes of this proposed program of research are to extend both the conceptual basis and range of treatment options for CAB of persons with IDD. Among the noteworthy aspects of this proposed program of research are that studies will be carried out by investigators known for the study and treatment of CAB and at three separate centers of excellence (i.e., three current IDDR Centers recognized as leaders in innovation and outstanding accomplishments for several decades). Such an approach to multi-site research has only been practical in the past few years with the dramatic advances in computer technology and telecommunications. Selection of investigators and sites can thus now be based on matching the experimental resources. Investigations conducted across the three research centers and four sites will focus on: (1) Examining the role of incentive shifts in triggering CAB and the development of interventions based on this novel conceptual framework; (2) Applying principles of behavioral economics to influence the choice of alternative constructive activities rather than CAB; and (3) Promoting generalization of therapy gains across settings, people and circumstances. An Administrative Core and Methodological Integrity Core will support the proposed research. Evidence arising from this multi-site, multi-faceted approach to the treatment of CAB in IDD will make it possible to design better therapeutic individuals with IDD to lead better lives.