Translational Analyses of Chronic Aberrant Behavior Across the Life Span

描述（由申请人提供）：行为障碍，包括攻击和自伤，可能会给智力和发育障碍（IDD）患者及其护理人员造成相当大的痛苦，并导致已经负担过重的医疗保健系统的成本大幅增加。这种疾病，这里称为慢性异常行为（CAB），已被有效地治疗使用的程序，提供了行为分析领域，是基于操作性学习原则的转化研究。这项拟议研究方案的目的是扩大碘缺乏病患者CAB的概念基础和治疗选择范围。这项拟议的研究计划值得注意的方面之一是，研究将由以研究和治疗CAB而闻名的研究人员在三个独立的卓越中心（即，目前有三个IDDR中心被公认为几十年来创新和杰出成就的领导者）。这种多地点研究的方法只是在过去几年中随着计算机技术和电信的巨大进步才变得切实可行。因此，现在可以根据实验资源的匹配来选择研究者和研究中心。在三个研究中心和四个地点进行的调查将集中在：（1）检查激励转变在触发CAB中的作用，以及基于这一新概念框架的干预措施的发展;（2）应用行为经济学的原则来影响替代建设性活动而不是CAB的选择;（3）促进治疗收益在不同环境、人群和环境中的推广。行政核心和方法完整性核心将支持拟议的研究。从这种多部位，多方面的方法来治疗CAB的IDD的证据将有可能设计更好的治疗IDD的个人，导致更好的生活。

DESCRIPTION (provided by applicant): Behavior disorders, including aggression and self-injury, can cause considerable suffering for individuals with intellectual and developmental disabilities (IDD) and their care givers, as well as result in significant added costs to an already overburdened health care system. Such disorders, here termed Chronic Aberrant Behavior (CAB), have been effectively treated using procedures, provided by the field of Behavior Analysis, that are based on translational studies of operant learning principles. The purposes of this proposed program of research are to extend both the conceptual basis and range of treatment options for CAB of persons with IDD. Among the noteworthy aspects of this proposed program of research are that studies will be carried out by investigators known for the study and treatment of CAB and at three separate centers of excellence (i.e., three current IDDR Centers recognized as leaders in innovation and outstanding accomplishments for several decades). Such an approach to multi-site research has only been practical in the past few years with the dramatic advances in computer technology and telecommunications. Selection of investigators and sites can thus now be based on matching the experimental resources. Investigations conducted across the three research centers and four sites will focus on: (1) Examining the role of incentive shifts in triggering CAB and the development of interventions based on this novel conceptual framework; (2) Applying principles of behavioral economics to influence the choice of alternative constructive activities rather than CAB; and (3) Promoting generalization of therapy gains across settings, people and circumstances. An Administrative Core and Methodological Integrity Core will support the proposed research. Evidence arising from this multi-site, multi-faceted approach to the treatment of CAB in IDD will make it possible to design better therapeutic individuals with IDD to lead better lives.