Mental Retardation and Developmental Disabilities Research Centers 2008

精神发育迟滞和发育障碍研究中心 2008 年

• 批准号: 7908739
• 负责人: MICHAEL F CATALDO
• 金额: $ 128.36万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908739
• 关键词: Mental; Retardation; Developmental; Disabilities; Research

This application for continued support of Years 21 through 25 of the Mental Retardation and Developmental Disabilities Research Center (MRDDRC) at the Kennedy Krieger Institute and Johns Hopkins University is submitted in response to RFA-HD-07-012. The MRDDRC consists of the Administrative Core (Core A) with four subdivisions, and four research cores (Cores B, C, D, and E). Core A (Administrative), provides overall leadership, management, and organizational support to the Center, operates the educational component (lectures and seminars), links users to biostatistical services (a research subdivision), assists with preparation of IRB materials, monitors issues of human research protection, and develops participant registries. Core B (Genetics) provides centralized tissue culture, amino acid/organic acid analyses, standard and molecular cytogenetics, specialized molecular genetics (DNA and RNA analyses) microarrarys and bioinformatics. Core C (Neuroscience) provides synaptic neurochemistry (focusing on histology imaging and high performance liquid chromatography) and lipid biochemistry (lipid metabolism, fatty acid analysis, and mass spectrometry services). Core D (Neuroimaging) provides for acquisition and quantitative analysis of data derived from functional, volumetic, diffusion tensor, and spectroscopic MR imaging. Core E (Behavior Science) offers training of subjects for cooperation with research protocols, selection and administration of standardized tests (developmental, cognitive, and functional), direct observations of behavior, design of activation paradigms for fMRI, and motion analysis (e.g., quantitative computer-assisted methods of documenting gaits, reaching, and learning behaviors within the motor domain). The core units serve 156 projects representing current direct annual NIH support totaling over $104 million dollars. The program addresses 30 of the 31 priority areas set forth in the RFA-HD-07-012, featuring interdisciplinary collaboration and a central theme, brain mechanisms whereby genotypes result in specific cognitive and behavioral phenotypes of mental retardation or developmental disability.

本申请是为了回应 RFA-HD-07-012，提交了继续支持肯尼迪克里格研究所和约翰霍普金斯大学智力迟钝和发育障碍研究中心 (MRDDRC) 21 至 25 年级的申请。 MRDDRC 由行政核心（核心 A）和四个细分部门以及四个研究核心（核心 B、C、D 和 E）组成。 核心A（行政），为中心提供全面领导、管理和组织支持，运营教育部分（讲座和研讨会），将用户与生物统计服务（研究部门）联系起来，协助准备IRB材料，监测人类研究保护问题，并开发参与者登记册。 核心 B（遗传学）提供集中组织培养、氨基酸/有机酸分析、标准和分子细胞遗传学、专业分子遗传学（DNA 和 RNA 分析）微阵列和生物信息学。 Core C（神经科学）提供突触神经化学（专注于组织学成像和高效液相色谱）和脂质生物化学（脂质代谢、脂肪酸分析和质谱服务）。 Core D（神经成像）可对来自功能、体积、扩散张量和光谱 MR 成像的数据进行采集和定量分析。 核心 E（行为科学）提供与研究方案合作的受试者培训、标准化测试（发育、认知和功能）的选择和管理、行为的直接观察、功能磁共振成像激活范式的设计和运动分析（例如，记录运动领域内的步态、到达和学习行为的定量计算机辅助方法）。 核心单位服务于 156 个项目，代表当前 NIH 年度直接支持总额超过 1.04 亿美元。 该计划涉及 RFA-HD-07-012 中提出的 31 个优先领域中的 30 个，其特点是跨学科合作和中心主题，即基因型导致精神发育迟滞或发育障碍的特定认知和行为表型的大脑机制。