Personalized Medicine for Colorectal and Breast Cancer

结直肠癌和乳腺癌的个性化医疗

• 批准号: 7925769
• 负责人: KATHRYN A PHILLIPS
• 金额: $ 149.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-16 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7925769
• 关键词: Personalized; Medicine; Colorectal; Breast; Cancer

DESCRIPTION (provided by applicant): This Program Project Grant proposal addresses personalized medicine - health care targeting medical interventions to patients based on their individual characteristics, particularly their genetics. Our objective is to use an integrated, interdisciplinary approach to obtain evidence about key aspects of the translation of genomic information for breast and colorectal cancer into clinical practice and health policy. Our Program includes four Projects and two Cores with the Specific Aims to: Aim 1: Determine utilization of genomic risk stratification and targeted treatment by using the examples of gene expression profiling (GEP) and HER2/neu testing for trastuzumab (Herceptin(r)) for breast cancer. Aim 2: Develop an understanding of preferences for genomic testing and interventions using the example of Lynch-syndrome screening. Aim 3: Develop a generalized, flexible model for evaluating the cost-effectiveness of personalized medicine and estimate the cost-effectiveness of GEP, HER2/neu testing for trastuzumab, and Lynch syndrome screening using unique data from our Program Projects. Aim 4: Develop an evidence base for translating research findings into practice and policy by collecting and synthesizing data on the clinical applications and the regulatory, policy, and economic impacts of genetically based colorectal and breast cancer interventions. Aim 5: Provide Projects with resources for: conceptualizing, measuring, and investigating population differences; conducting qualitative and quantitative research; identifying and obtaining data sources; coordinating activities; and disseminating findings. The significance of this proposal lies in our goal to establish evidence-based information that will be useful to patients, clinicians, providers, researchers, and policymakers in assessing how personalized medicine can be most beneficial and efficient. Our results will have implications beyond the specific cancers studied, as the issues related to utilization, access, preferences, economics, value, and policy implications are relevant across cancer sites and interventions.

描述(由申请者提供)：本计划项目资助提案旨在根据患者的个体特征，特别是他们的遗传特征，针对患者的医疗干预，提供个性化的医疗保健。我们的目标是使用一种综合的、跨学科的方法来获得关于乳腺癌和结直肠癌基因组信息转化为临床实践和卫生政策的关键方面的证据。我们的计划包括四个项目和两个核心，具体目标是： 目的1：以曲妥珠单抗(Herceptin(R))的基因表达谱(GEP)和HER2/neu检测为例，确定基因组风险分层和靶向治疗的应用。 目的2：以林奇综合征筛查为例，了解基因组检测和干预的偏好。 目的3：建立一个通用的、灵活的模型来评估个性化药物的成本-效果，并使用我们计划项目中的独特数据评估GEP、曲妥珠单抗的HER2/neu检测和Lynch综合征筛查的成本-效果。 目的4：通过收集和综合基于基因的结直肠癌和乳腺癌干预措施的临床应用以及监管、政策和经济影响的数据，为将研究成果转化为实践和政策建立证据基础。 目标5：为以下项目提供资源：概念化、衡量和调查人口差异；进行定性和定量研究；确定和获得数据来源；协调活动；传播调查结果。 这项建议的意义在于我们的目标是建立基于证据的信息，这些信息将对患者、临床医生、提供者、研究人员和政策制定者在评估个性化医疗如何最有益和最有效方面有用。我们的结果将具有超越所研究的特定癌症的影响，因为与利用、获取、偏好、经济、价值和政策影响相关的问题与癌症地点和干预措施相关。

项目成果

Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.

• DOI: 10.1038/gim.2017.21
• 发表时间: 2017-10
• 期刊: Genetics in medicine : official journal of the American College of Medical Genetics
• 作者: Phillips KA;Deverka PA;Sox HC;Khoury MJ;Sandy LG;Ginsburg GS;Tunis SR;Orlando LA;Douglas MP
• 通讯作者: Douglas MP

Value of Genetic Testing for Hereditary Colorectal Cancer in a Probability-Based US Online Sample.

基于概率的美国在线样本中，遗传性结直肠癌的基因检测值。

• DOI: 10.1177/0272989x14565820
• 发表时间: 2015-08-01
• 期刊: Medical decision making : an international journal of the Society for Medical Decision Making
• 作者: Knight SJ;Mohamed AF;Marshall DA;Ladabaum U;Phillips KA;Walsh JM
• 通讯作者: Walsh JM

Capacity building for assessing new technologies: approaches to examining personalized medicine in practice.

• DOI: 10.2217/pme.10.36
• 发表时间: 2010-07
• 期刊: Personalized medicine
• 影响因子: 2.3
• 作者: Van Bebber SL;Trosman JR;Liang SY;Wang G;Marshall DA;Knight S;Phillips KA
• 通讯作者: Phillips KA

Using the coronary artery calcium score to guide statin therapy: a cost-effectiveness analysis.

• DOI: 10.1161/circoutcomes.113.000799
• 发表时间: 2014-03
• 期刊: Circulation. Cardiovascular quality and outcomes
• 作者: Pletcher MJ;Pignone M;Earnshaw S;McDade C;Phillips KA;Auer R;Zablotska L;Greenland P
• 通讯作者: Greenland P

Closing the personalized medicine information gap: HER2 test documentation practice.

缩小个性化医疗信息差距：HER2 测试文档实践。

• 发表时间: 2013
• 期刊: The American journal of managed care
• 作者: Ferrusi,IliaL;Earle,CraigC;Trudeau,Maureen;Leighl,NatashaB;Pullenayegum,Eleanor;Khong,Hoa;Hoch,JeffreyS;Marshall,DeborahA
• 通讯作者: Marshall,DeborahA