TYPE I DIABETES GENETIC CONSORTIUM (NORTH AMERICAN REGIONAL NETWORK)

I 型糖尿病遗传联盟（北美区域网络）

• 批准号: 8166680
• 负责人: LUISA M RODRIGUEZ
• 金额: $ 1.64万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166680
• 关键词: Affect; African American; American; Area; Asia; Biological; Blood specimen; Child; Chromosome Mapping; Clinical; Communities; Computer Retrieval of Information on Scientific Projects Database; DNA; Databases; Enrollment; Ethnic group; Europe; Family; Funding; Genes; Genetic Structures; Geographic Locations; Goals; Grant; Individual; Institution; Insulin-Dependent Diabetes Mellitus; International; Latin America; Methods; Mexican Americans; North America; Parents; Pediatric Hospitals; Prevention therapy; Recruitment Activity; Research; Research Personnel; Resources; Risk; Siblings; Source; Susceptibility Gene; Texas; United Kingdom; United States National Institutes of Health; base; diabetes mellitus genetics; genetic resource; genome-wide linkage; meetings; non-diabetic; repository; type I diabetic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Type 1 Diabetes Genetics Consortium (T1DGC) will organize international efforts to identify genes that determine an individual s risk for type 1 diabetes. Progress towards this goal, worldwide, has been limited by a lack of sufficient clinical and genetic resources. The creation of a resource-base of well-characterized families from multiple ethnic groups is sought that will facilitate the localization and characterization of type 1 diabetes genes based on statistically powered genome-wide linkage studies. We would like to enroll Texas children s Hospital as one of the centers for recruitment in the North American Network. Currently, there are 47 centers in the U.S. participating in this international effort, aiming to characterize genes related to Type 1 diabetes. The scientific objectives of the Type 1 Diabetes Genetics Consortium are: 1. To ascertain, study and establish a renewable source of DNA on 3000 affected sib-pair (ASP) families with at least two type 1 diabetic siblings, +/- their parents, and +/- up to two non-diabetic siblings for studies to map genes that may be associated with type 1 diabetes; 2. To ascertain, study and establish a renewable source of DNA on 5000 trio families with one type 1 diabetic child and both their parents, if the biological parents self -identify as African American or Mexican American . 3. To ascertain, study and establish a renewable source of DNA on 1800 individuals self-identifying as African American and or/ Mexican American, 900 with (control) type 1 diabetes and 900 without (case) type 1 diabetes. 4. To create a database for the scientific community that would facilitate the search for type 1 diabetes susceptibility genes; 5. To provide a centralized DNA repository to allow targeted studies of genetic structure and function for type 1 diabetes; 6. To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy in the area of type 1 diabetes. 7. To meet these objectives, the T1DGC will collect information and blood samples from sib-pair and trio families located in five study-defined geographic areas worldwide: Asia-Pacific, Europe, Latin America, North America, and the United Kingdom. The North American Network will also be recruiting individuals self-identifying as African American and or/ Mexican American, with type 1 diabetes and without type 1 diabetes.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 1型糖尿病遗传学联盟（T1 DGC）将组织国际努力，以确定决定个人1型糖尿病风险的基因。由于缺乏足够的临床和遗传资源，世界范围内实现这一目标的进展受到限制。创建一个资源库的良好特征的家庭，从多个种族群体的目的，将有利于本地化和1型糖尿病基因的特征的基础上，统计动力全基因组连锁研究。我们希望将德克萨斯儿童医院作为北美网络的招聘中心之一。目前，美国有47个中心参与了这项国际努力，旨在表征与1型糖尿病相关的基因。 1型糖尿病遗传学联盟的科学目标是： 1. 确定，研究和建立3000个受影响的兄弟姐妹对（ASP）家庭的DNA的可再生来源，其中至少有两个1型糖尿病兄弟姐妹，+/-他们的父母，和+/-多达两个非糖尿病兄弟姐妹，用于研究可能与1型糖尿病相关的基因图谱; 2. 确定，研究和建立一个可再生的DNA来源，对5000个三人家庭，一个1型糖尿病儿童和他们的父母，如果亲生父母自我认同为非洲裔美国人或墨西哥裔美国人。 3. 确定，研究和建立一个可再生的DNA来源的1800个人自我识别为非洲裔美国人和/或墨西哥裔美国人，900（对照）1型糖尿病和900（情况）1型糖尿病。 4. 为科学界建立一个数据库，以便于寻找1型糖尿病易感基因; 5. 提供一个集中的DNA储存库，以便对1型糖尿病的遗传结构和功能进行有针对性的研究; 6. 评估扩大研究成果的机会，以开发1型糖尿病领域的风险预测、预防和治疗方法。 7. 为了实现这些目标，T1 DGC将从位于全球五个研究定义的地理区域（亚太、欧洲、拉丁美洲、北美和英国）的同胞对和三人家庭中收集信息和血液样本。北美网络还将招募自认为是非洲裔美国人和/或墨西哥裔美国人的1型糖尿病患者和非1型糖尿病患者。