Mount Sinai Institutes for Clinical and Translational Sciences

西奈山临床和转化科学研究所

• 批准号: 8060582
• 负责人: Barbara T. Murphy
• 金额: $ 85.59万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-14 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8060582
• 关键词: Caregivers; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Collaborations; Communities; Consultations; Country; Development; Environment; Fostering; Future; General Population; Goals; Grant; Health Benefit; Health Professional; Home environment; Hospitals; Information Networks; Institutes; Institution; Instruction; Laboratories; Mentors; Methodology; Participant; Patients; Procedures; Recruitment Activity; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Rewards; Science; Scientific Advances and Accomplishments; Scientist; Structure; Technology; Therapeutic; Training; Training Support; Translating; Translational Research; Translations; bench to bedside; career development; clinical practice; improved; interdisciplinary collaboration; medical schools; multidisciplinary; novel; programs; standard of care

Despite great scientific advances over the past decade, the translation of these discoveries to the benefit of patients has been hampered by a number of traditional barriers. The overall goal of the iWioyinit Siimai ImstitiLiiites of ClBrnical & Tiramslatioinial Sciences is to establish a new research paradigm at Mount Sinai, which will create an integrated multidisciplinary environment that will enable translation of cutting-edge research more quickly and easily from "bench-to-bedside-to-implementation" in the community; train and create an "academic home" for the clinical and translational investigators of tomorrow; and supply the governance, facilities, resources and opportunities needed to elevate the clinical research enterprise so that clinical investigators can take full advantage of Mount Sinai's Translational Research Institutes and potential collaborators in Mount Sinai Hospital and its affiliates, the School of Medicine and partnering institutions, and other CTSA programs around the country. This transformation will be achieved by fulfilling the following Specific Aims: (1) redesign the institutional research enterprise infrastructure and governance by integrating research functions across administrative, departmental and intellectual boundaries, enhancing and promoting interactions between basic scientists and clinical investigators, and streamlining administrative procedures to facilitate the start-up of clinical trials and the dissemination of results; (2) establish a Translational Discoveries Program to facilitate and expedite clinical research by providing consultation, oversight and facilities for clinical and translational research, engaging the surrounding community and our affiliates to rapidly translate health benefits to the general population, and developing new methodologies to improve clinical trial design and reduce participant burden; (3) train and support the translational investigators of tomorrow by overseeing a multi-disciplinary, doctoral degree-granting program in clinical and translational research for all health care professionals, developing a program to recruit, enhance career development and retain clinical and translational researchers, providing an academic home where new collaborations can be formulated; (4) establish an Experimental Therapeutics& Technologies Program to stimulate the development of new methodologies in clinical and translational research by developing an institution-wide mentored program to identify and develop novel clinical and translational research projects; and (5) establish an institution-wide biomedical information infrastructure that can connect basic researchers, clinical researchers, caregivers and laboratories with an integrated network of information. RELEVANCE (See instructions): The establishment of the ilfloynt Siinao Institutes of Clinical & Tiranslational Sciemces would create an effective, efficient and centralized research administrative structure, foster and reward interdisciplinary collaborations, educate and retain the clinical and translational investigators of the future, enable translation of basic scientific discoveries into clinical practice, and deliver to our diverse community new therapies and a standard of care that would have been unimaginable even five years ago.

尽管在过去的十年里，科学取得了巨大的进步，但这些发现的翻译对人类有益

项目成果

A pilot prospective study of fetomaternal hemorrhage identified by anemia in asymptomatic neonates.

• DOI: 10.1038/jp.2015.211
• 发表时间: 2016-05
• 期刊: Journal of perinatology : official journal of the California Perinatal Association
• 作者: Stroustrup A;Plafkin C
• 通讯作者: Plafkin C

Demographics, clinical characteristics and outcomes of neonates diagnosed with fetomaternal haemorrhage.

诊断为母胎出血的新生儿的人口统计、临床特征和结局。

• DOI: 10.1136/archdischild-2011-300820
• 发表时间: 2012
• 期刊: Archives of disease in childhood. Fetal and neonatal edition
• 作者: Stroustrup,Annemarie;Trasande,Leonardo
• 通讯作者: Trasande,Leonardo

Demographic and Behavioral Predictors of Severe Fetomaternal Hemorrhage: A Case-Control Study.

严重胎儿母体出血的人口统计学和行为预测因素：病例对照研究。

• DOI: 10.1159/000442082
• 发表时间: 2016
• 期刊: Neonatology
• 影响因子: 2.5
• 作者: Stroustrup,Annemarie;Plafkin,Callie;Tran,Thuy-An;Savitz,DavidA
• 通讯作者: Savitz,DavidA

Multi-ethnic cytochrome-P450 copy number profiling: novel pharmacogenetic alleles and mechanism of copy number variation formation.

• DOI: 10.1038/tpj.2012.48
• 发表时间: 2013-12
• 期刊: The pharmacogenomics journal
• 作者: Martis S;Mei H;Vijzelaar R;Edelmann L;Desnick RJ;Scott SA
• 通讯作者: Scott SA

KLF6-SV1 drives breast cancer metastasis and is associated with poor survival.

• DOI: 10.1126/scitranslmed.3004688
• 发表时间: 2013-01-23
• 期刊: Science translational medicine
• 影响因子: 17.1
• 作者: Hatami R;Sieuwerts AM;Izadmehr S;Yao Z;Qiao RF;Papa L;Look MP;Smid M;Ohlssen J;Levine AC;Germain D;Burstein D;Kirschenbaum A;DiFeo A;Foekens JA;Narla G
• 通讯作者: Narla G