Cardiac Physiology and Imaging Core for Mouse in Vivo

小鼠体内心脏生理学和成像核心

• 批准号: 8111954
• 负责人: KIRK L PETERSON
• 金额: $ 31.07万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8111954
• 关键词: Area; Cardiac; Cardiac Catheterization Procedures; Cardiovascular Diseases; Core Facility; Echocardiography; Engineering; Exercise; Gene Transfer; Goals; Heart failure; Hypertrophy; Image; Individual; Left; Magnetic Resonance Imaging; Methods; Modeling; Monitor; Morphology; Mus; Myocardial Infarction; Performance; Physiological; Physiology; Research Personnel; Right ventricular structure; Stress; Ventricular Remodeling; gene function; hemodynamics; in vivo; microangiography; pressure; programs

Introduction The goals of this core facility are to serve all of the investigators and projects within this Program Project in three major areas: 1. Provide heart catheterization, treadmill stress exercise performance, and telemetric hemodynamic monitoring for detailed physiologic characterization, as well as transthoracic echocardiography, magnetic resonance imaging and iodinated contrast microangiography for functional cardiac morphology, of genetically engineered murine models of cardiovascular disease. 2. Apply microsurgical methods in mice for inducing a pressure overload on either the left or right ventricle, or to produce myocardial infarction, in order to induce ventricular remodeling with hypertrophy or heart failure. 3. Induce high efficiency in vivo cardiac gene transfer in mice, where needed, to assess individual gene function.

介绍 该核心设施的目标是为该计划项目中的所有调查人员和项目提供服务 三个主要领域： 1。提供心脏导管插入术，跑步机压力运动表现和遥测血液动力学 监测详细的生理表征以及经胸超声心动图，磁性 遗传学上的功能性心脏形态的共振成像和碘化对比度摄影 设计的心血管疾病的鼠模型。 2。在小鼠中应用微神经方法，以诱导左室或右心室的压力超负荷，或 为了产生心肌梗塞，以诱导肥大或心力衰竭的心室重塑。 3。诱导小鼠体内心脏基因转移的高效率，以评估单个基因 功能。