Cardiac Physiology and Imaging Core for Mouse in Vivo

引言 这一核心设施的目标是为该计划项目中的所有调查人员和项目提供服务 三个主要领域： 1.提供心脏导管术、跑步机负荷运动性能和遥测血流动力学 监测详细的生理特征，以及经胸超声心动图，磁力 磁共振成像和碘对比微血管造影术对遗传性心脏功能形态的研究 心血管疾病的转基因小鼠模型。 2.在小鼠身上应用显微外科方法，在左或右室造成压力超负荷，或 产生心肌梗死，以诱导心肌肥厚或心力衰竭时的心室重构。 3.在需要的情况下，在小鼠体内诱导高效的心脏基因转移，以评估单个基因 功能。

Introduction The goals of this core facility are to serve all of the investigators and projects within this Program Project in three major areas: 1. Provide heart catheterization, treadmill stress exercise performance, and telemetric hemodynamic monitoring for detailed physiologic characterization, as well as transthoracic echocardiography, magnetic resonance imaging and iodinated contrast microangiography for functional cardiac morphology, of genetically engineered murine models of cardiovascular disease. 2. Apply microsurgical methods in mice for inducing a pressure overload on either the left or right ventricle, or to produce myocardial infarction, in order to induce ventricular remodeling with hypertrophy or heart failure. 3. Induce high efficiency in vivo cardiac gene transfer in mice, where needed, to assess individual gene function.