Novel minimally-invasive in-situ 3D bioprinting platform for cardiac regeneration
用于心脏再生的新型微创原位3D生物打印平台
基本信息
- 批准号:EP/X027287/2
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Fellowship
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Currently, cardiac disorders (e.g., infarction, arrythmia, ischemia, etc.) are one of the leading causes of death according to WHO. In this project I aim to use interdisciplinary approaches to develop a novel in-situ 3D bioprinting (inSituBioprint) platform for cardiac regeneration, to directly fabricate patient-specific cardiac patches on host tissue. This will produce a new generation of 3D printing method for automatic implantation, which will drastically improve the surgical outcomes and patients' well-being. In the proposed study, a minimally-invasive 3D bioprinting platform will be designed to access tissue only through small incision, which fully recapitulates the concept of laparoscopy (keyhole surgery). Rather than following pre-planned printing paths, the proposed printer will sense, learn, and adapt to the curved surface during printing, and the height of the nozzle-substrate gap will be determined via impedance spectroscopic sensing and machine learning (ML) facilitated spectra analysis. Based on this platform, the conductive copolymer will be synthesized and optimised for in situ printing. Finally, I will investigate the therapeutic efficacy and regenerative potential of the conductive cardiac patch using three cardiac models: nonviable porcine heart (dimensionally similar to human heart), 3D cardiomyocyte culture, and cryoinjured arrythmia myocardial slice model. The proposed study will validate a clinically-relevant 3D bioprinting technique to accelerate the translation of surgical robotics and tissue regeneration, and eventually to benefit patient undergoing surgeries.
目前,心脏病(例如,梗塞、心律失常、局部缺血等)是导致死亡的主要原因之一。在这个项目中,我的目标是使用跨学科的方法来开发一种新的原位3D生物打印(inSituBioprint)平台,用于心脏再生,直接在宿主组织上制造患者特定的心脏贴片。这将产生新一代用于自动植入的3D打印方法,这将大大改善手术结果和患者的健康。在拟议的研究中,将设计一种微创3D生物打印平台,仅通过小切口进入组织,这完全概括了腹腔镜手术(锁孔手术)的概念。不是遵循预先计划的打印路径,所提出的打印机将在打印期间感测、学习和适应弯曲表面,并且将经由阻抗光谱感测和机器学习(ML)促进的光谱分析来确定基板-基板间隙的高度。基于这个平台,导电共聚物将被合成并优化用于原位印刷。最后,我将使用三种心脏模型研究导电心脏贴片的治疗效果和再生潜力:无活力的猪心(尺寸类似于人类心脏),3D心肌细胞培养和冷冻损伤的心律失常心肌切片模型。这项拟议的研究将验证一种临床相关的3D生物打印技术,以加速手术机器人和组织再生的转化,并最终使接受手术的患者受益。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Molly Stevens其他文献
Molly Stevens的其他文献
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{{ truncateString('Molly Stevens', 18)}}的其他基金
Unravelling coupling between multiscale tissue mechanics and heart valve calcification
揭示多尺度组织力学与心脏瓣膜钙化之间的耦合
- 批准号:
EP/X027163/2 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Fellowship
Say Yes to NO: The Next Generation Scaffolds with Localized and Sustained Nitric Oxide (NO) Delivery for Central Nervous System Regeneration
对“否”说“是”:具有局部和持续一氧化氮 (NO) 输送的下一代支架,用于中枢神经系统再生
- 批准号:
EP/X027198/2 - 财政年份:2024
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-- - 项目类别:
Fellowship
Development of a 3D-printed anisotropic heart-on-a-chip for drug screening applications
开发用于药物筛选应用的 3D 打印各向异性芯片心脏
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EP/X02721X/2 - 财政年份:2024
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Fellowship
Self-Illuminated PDT Platform for Highly Specific Diagnosis and Therapeutics for Deep Sited Tumor
用于深部肿瘤高度特异性诊断和治疗的自发光 PDT 平台
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EP/Y036646/1 - 财政年份:2024
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Fellowship
BODIPY Photocage-Enabled Visualization and Optical Control of saRNA Delivery and Immunogenicity
BODIPY Photocage 实现 saRNA 传递和免疫原性的可视化和光学控制
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EP/X027252/2 - 财政年份:2024
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Fellowship
Bioinspired Multiplexed Ultrasensitive Biosensing
仿生多重超灵敏生物传感
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EP/Z000130/1 - 财政年份:2024
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Research Grant
Unravelling coupling between multiscale tissue mechanics and heart valve calcification
揭示多尺度组织力学与心脏瓣膜钙化之间的耦合
- 批准号:
EP/X027163/1 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Fellowship
Development of a 3D-printed anisotropic heart-on-a-chip for drug screening applications
开发用于药物筛选应用的 3D 打印各向异性芯片心脏
- 批准号:
EP/X02721X/1 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Fellowship
BODIPY Photocage-Enabled Visualization and Optical Control of saRNA Delivery and Immunogenicity
BODIPY Photocage 实现 saRNA 传递和免疫原性的可视化和光学控制
- 批准号:
EP/X027252/1 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Fellowship
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