ASSESSMENT OF CRH RECEPTOR ANTAGONIST FOR SELF-INJURIOUS BEHAVIOR IN MACAQUES

CRH 受体拮抗剂对猕猴自伤行为的评估

• 批准号: 8357487
• 负责人: Karen Renee Strait
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357487
• 关键词: Alternative Therapies; American; Animal Welfare; Animals; Anti-Anxiety Agents; Behavior; Biomedical Research; Buspirone; CRH gene; Clinical; Corticotropin-Releasing Hormone Receptors; Data; Funding; Grant; Health; Housing; Hydrocortisone; Macaca; Macaca mulatta; Methods; Monkeys; National Center for Research Resources; Primates; Principal Investigator; Process; Research; Research Infrastructure; Resources; Self-Injurious Behavior; Societies; Source; Symptoms; United States National Institutes of Health; base; cost; design; improved; meetings; receptor; research facility

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Self-injurious behavior is one of the most troublesome clinical conditions in rhesus monkeys housed in biomedical research facilities, for which current treatment methods are often ineffective. This study was originally designed to evaluate the efficacy of a CRH1 receptor antagonist in reducing self-injurious behavior (SIB) in captive housed rhesus macaques. During the early part of the study, preliminary data indicated that the CRH1 receptor antagonist consistently increased cortisol levels in monkeys. Based on this unexpected finding, we decided to forgo treatment with the CRH antagonist to avoid exacerbating symptoms and instead focus on alternative therapies. We are currently evaluating treatment for self-injurious and stereotypical behavior with the anxiolytic buspirone. Data has been collected from 8 animals and we are in the process of identifying an additional 2 animals for study. Preliminary results were presented at the American Society of Primatologists 2010 annual meeting. Data from this study has the potential to greatly impact the clinical health of rhesus monkeys both at our center and at other biomedical research facilities, improving animal welfare and allowing for quality research.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在生物医学研究设施中，自我伤害行为是恒河猴最麻烦的临床症状之一，目前的治疗方法往往对此无效。这项研究最初是为了评估CRH1受体拮抗剂在减少圈养恒河猴自残行为(SIB)方面的效果。在研究的早期阶段，初步数据表明，CRH1受体拮抗剂持续增加猴子的皮质醇水平。基于这一意想不到的发现，我们决定放弃CRH拮抗剂的治疗，以避免症状恶化，转而专注于替代疗法。我们目前正在评估抗焦虑药物丁螺环酮对自我伤害和刻板印象行为的治疗。已经从8只动物那里收集了数据，我们正在确定另外2只动物进行研究。初步研究结果在美国灵长类动物学家协会2010年年会上公布。这项研究的数据有可能极大地影响我们中心和其他生物医学研究机构的恒河猴的临床健康，改善动物福利，并允许进行高质量的研究。