ASSESSMENT OF CRH RECEPTOR ANTAGONIST FOR SELF-INJURIOUS BEHAVIOR IN MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在没有可识别病原体的情况下慢性腹泻和自我伤害行为是生物医学研究设施中饲养的恒河猴最麻烦的两种临床状况，目前的治疗方法往往对此无效。在这些情况下，长期暴露在心理社会压力中起到了一定作用。这项研究最初是为了评估CRH1受体拮抗剂在减少圈养猕猴慢性腹泻和自伤行为(SIB)方面的效果。 在这项研究的早期，初步数据表明，CRH1受体拮抗剂持续增加猴子的皮质醇水平。基于这一意想不到的发现，我们决定放弃CRH拮抗剂的治疗，以避免症状恶化，转而专注于替代疗法。我们目前正在评估抗焦虑药物丁螺环酮对自我伤害和刻板印象行为的治疗。在本报告所述期间，我们收集了6只动物的数据，目前正在收集另外4只动物的数据。此外，我们正在确定慢性腹泻的新治疗策略，并计划评估有前途的候选药物。从这项研究获得的数据有可能极大地影响我们中心和其他生物医学研究机构的恒河猴的临床健康，改善动物福利，并允许进行高质量的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic diarrhea in the absence of identifiable pathogens and self-injurious behavior are two of the most troublesome clinical conditions in rhesus monkeys housed in biomedical research facilities, for which current treatment methods are often ineffective. Chronic exposure to psychosocial stress plays a role in these conditions. This study was originally designed to evaluate the efficacy of a CRH1 receptor antagonist in reducing chronic diarrhea and self-injurious behavior (SIB) in captive housed rhesus macaques. During the early part of this study, preliminary data indicated that the CRH1 receptor antagonist consistently increased cortisol levels in monkeys. Based on this unexpected finding, we decided to forgo treatment with the CRH antagonist to avoid exacerbating symptoms and instead focus on alternative therapies. We are currently evaluating treatment for self-injurious and stereotypical behavior with the anxiolytic buspirone. During the reporting period, we collected data from 6 animals and are in the process of collecting data from 4 additional animals. Additionally, we are identifying new treatment strategies for chronic diarrhea with plans to evaluate promising candidates. Data obtained from this study has the potential to greatly impact the clinical health of rhesus monkeys both at our center and at other biomedical research facilities, improving animal welfare and allowing for quality research.