ASSESSMENT OF CRH RECEPTOR ANTAGONIST FOR SELF-INJURIOUS BEHAVIOR IN MACAQUES

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究评估CRH 1受体拮抗剂在减少圈养恒河猴慢性腹泻和自伤行为（SIB）中的功效。 慢性腹泻在没有可识别的病原体和SIB是两个 在生物医学研究设施中饲养的恒河猴中最麻烦的临床病症，目前的治疗方法往往无效。 长期暴露于心理社会压力在这些情况中起作用。 新出现的数据表明，促肾上腺皮质激素释放激素（CRH）介导的压力引起的焦虑和抑郁症，这些情绪问题得到纠正的治疗与特定的CRH 1受体拮抗剂。此外，这种治疗还减弱了应激诱导的肠道运动和腹泻的发生率。 本研究的目的是确定CRH 1受体拮抗剂治疗是否可以在不存在肠道病原体的情况下改善慢性腹泻和/或减少恒河猴的SIB。 从这项研究中获得的数据有可能极大地影响我们中心和其他生物医学研究机构的恒河猴的临床健康，改善动物福利并允许高质量的研究。 在报告期内，我们完成了一小群慢性腹泻猴子的数据收集。 我们目前正在确定用于研究分配的其他动物。改善殖民地健康的措施将促进该中心的各种研究计划，包括艾滋病疫苗的开发。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study evaluates the efficacy of a CRH1 receptor antagonist in reducing chronic diarrhea and self-injurious behavior (SIB) in captive housed rhesus macaques. Chronic diarrhea in the absence of identifiable pathogens and SIB are two of the most troublesome clinical conditions in rhesus monkeys housed in biomedical research facilities, for which current treatment methods are often ineffective. Chronic exposure to psychosocial stress plays a role in these conditions. Emerging data indicate that corticotropin releasing hormone (CRH) mediates stress-induced anxiety and depression, and that these emotional problems are corrected by treatment with specific CRH1 receptor antagonists. Furthermore, this treatment also attenuates stress-induced gut motility and the incidence of diarrhea. The purpose of this study is to determine whether treatment with a CRH1 receptor antagonist can ameliorate chronic diarrhea in the absence of enteric pathogens and/or reduce SIB in rhesus macaques. Data obtained from this study has the potential to greatly impact the clinical health of rhesus monkeys both at our center and at other biomedical research facilities, improving animal welfare and allowing for quality research. During the reporting period, we completed data collection in a small group of monkeys with chronic diarrhea. We are currently identifying additional animals for study assignment. Measures that improved the health of the colony will facilitate the diverse research program of the Center including AIDS vaccine development.