IDENTIFYING CARDIAC DISEASE IN CHIMPANZEES WITH ECHOCARDIOGRAMS AND BIOMARKERS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 由心肌纤维化引起的心脏病已被证明是圈养黑猩猩种群中最常见的死亡原因。心肌纤维化可导致心力衰竭或心脏性猝死。心电图、血压监测和超声心动图已被用于筛查心脏病，但并不总是检测纤维化的最佳工具。在人类中，血清生物标记物被用来识别心脏病。这些生物标记物中的几个正在被评估为预测黑猩猩心脏病的潜在工具。然而，这些生物标记物似乎是物种特有的，并与导致心脏病的病理类型有关。由迈克尔·拉米和约翰·伊利领导的阿拉莫戈多灵长类动物设施的一个合作小组正在对心肌肌钙蛋白、BNP和其他几个生物标志物进行评估。该项目是Charles River和Yerkes之间的合作努力，以帮助描述黑猩猩的心脏生物标记物特征。在过去的一年里，大约有10只黑猩猩被采集了血清，用于结合EKG和超声心动图进行生物标记物分析。生物标志物样本已被运往加州大学戴维斯分校进行分析，数据将与心脏检查结果相关联。生物标志物样本的收集已经完成，但超声心动图将继续进行。超声心动图将根据大猿心脏病项目的结果进行标准化。超声心动图将以标准化的格式记录下来，以便能够与其他机构的结果进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cardiac disease due to myocardial fibrosis has been documented as the most common cause of death in captive chimpanzee populations. Myocardial fibrosis can result in heart failure or sudden cardiac death. EKGs, blood pressure monitoring, and echocardiography have been used to screen for cardiac disease, but are not always the best tools to detect fibrosis. In humans serum biomarkers are used to identify cardiac disease. Several of these biomarkers are being evaluated as a potential tool to predict heart disease I chimpanzees. However, the biomarkers appear to be species specific and related to the type of pathology causing heart disease. Cardiac troponin, BNP and several other biomarkers are being evaluated by a collaborative group led by Michael Lammey and John Ely at the Alamogordo Primate Facility. This project is a collaborative effort between Charles River and Yerkes to help characterize the cardiac biomarker profile in chimpanzees. Within the last year approximately 10 chimps have had serum collected for biomarker analysis in conjunction with EKG and echocardiography. The biomarker samples have been shipped to UC Davis for analysis, and the data will be correlated with cardiac examination results. The collection of biomarker samples has been completed but the echocardiograms will continue. The echocardiograms are going to be standardized based on results from The Great Ape Cardiac Disease project. Echocardiograms will then be recorded in a standardized format to be able to compare results with other institutions.