DIABETES MELLITIS IN SOOTY MANGABEYS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 自发性糖尿病已经在几个非人类灵长类物种中被报道，但还没有关于芒果类的记录。耶克斯国家灵长类研究中心有一群棕榈鸟，它们的发病率很高 糖尿病。1969年至2008年在尸检中收集的胰腺组织的回顾显示，在10岁以上的动物中，岛状淀粉样变性的发生率超过50%，这是非人类灵长类动物糖尿病的标志。我们相信，对我们的200多只山竹进行临床糖尿病的筛查，以及对这种疾病的临床、遗传和诊断表现的调查，将为烟尘山竹的糖尿病及其发病机制提供重要的信息。 到目前为止，我们已经收集了大约115只曼加比的样本来筛查糖尿病，并收集了50份样本来评估这些动物的胰岛素水平。对这些样本的初步分析证实，殖民地内糖尿病和糖尿病前期患者的发病率很高。此外，正常的血清化学特征和完整的血细胞计数参考范围将有助于糖尿病和其他影响人群的疾病的临床评估。我们收集了100多份曼加比的CBC和血清化学样本，建立了一个正常值数据库。这些样本显示了一些与其他非人类灵长类物种的正常化学值不同的芒果类动物的值。最后，确定哪一种是最好的糖尿病临床检测方法将有助于在我们的殖民地早期诊断和临床治疗这种疾病。我们已经收集了大约75个样本，用于两种特定的测试(果糖胺和糖化血红蛋白)，用于诊断和评估糖尿病控制情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Spontaneous diabetes mellitus has been reported in several nonhuman primate species, but has not been documented for the mangabey. The Yerkes National Primate Research Center has a colony of mangabeys with a high prevalence of diabetes. A review of pancreatic tissues, collected at necropsy from 1969-2008, revealed a greater than 50% incidence of insular amyloidosis, a hallmark of diabetes in nonhuman primates, in animals over ten years of age. We believe the screening of our colony of over 200 mangabeys for clinical diabetes, as well as, an investigation of the clinical, genetic, and diagnostic manifestation of the disease, would provide important information about diabetes mellitus and its pathogenesis in the sooty mangabey. To date, we have collected samples from approximately 115 mangabeys to screen for diabetes as well as 50 samples to evaluate insulin levels in these animals. Initial anaylsis of these samples confirms the high incidence of diabetes and pre-diabetics within the colony. In addition, characterization of normal serum chemistry and complete blood count reference ranges for mangabeys will aid in clinical evaluation of diabetes and other diseases affecting the population. We have collected over 100 CBC and serum chemistry samples from mangabeys to build a database of normal values. These samples demonstrate some values for mangabeys that are differ from the normal chemistry values of other species of non-human primates. Finally, identifying which is the best clinical test for diabetes melltus in the mangabey would allow for early diagnosis and clinical management of the disease in our colony. We have collected approximately 75 samples for 2 specific tests (fructosamine and glycosylated hemoglobin) that are used to diagnose and evaluate diabetic control.