IDENTIFYING CARDIAC DISEASE IN CHIMPANZEES WITH ECHOCARDIOGRAMS AND BIOMARKERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 最近，由心肌纤维化引起的心脏病已被证明是圈养黑猩猩种群中最常见的死亡原因。心肌纤维化可导致心力衰竭或心脏性猝死。心电图(EKG)、血压监测和超声心动图已被用于筛查心脏病，但并不总是检测纤维化的最佳工具。在人类医学中，血清生物标记物用于识别心脏病。不同可测量生物标志物的升高与潜在的病理相关，并有助于预测疾病。这些生物标记物中的几个正在被评估为预测黑猩猩心脏病的潜在工具。然而，这些生物标记物似乎是物种特有的，并与导致心脏病的病理类型有关。由Michael Lammey和John Ely领导的阿拉莫戈多灵长类动物设施的一个合作小组正在对心肌肌钙蛋白、BNP和其他几个生物标志物进行评估。 该项目是Charles River和耶克斯灵长类中心之间的合作努力，以帮助描述黑猩猩的心脏生物标记物特征。在过去的一年里，大约有10只黑猩猩被采集了血清，用于生物标记物分析，并与EKG和超声心动图一起进行，由注册的兽医心脏病专家或人类心脏病专家进行。生物标记物样本已被运往加州大学戴维斯分校进行分析，数据将与心脏检查结果相关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiac disease due to myocardial fibrosis has recently been documented as the most common cause of death in captive chimpanzee populations. Myocardial fibrosis can result in heart failure or sudden cardiac death. Electrocardiograms (EKG), blood pressure monitoring and echocardiography have been used to screen for cardiac disease but are not always the best tools to detect fibrosis. In human medicine, serum biomarkers are used to identify cardiac disease. Elevations in different measureable biomarkers are related to the underlying pathology and can help predict disease. Several of these biomarkers are being evaluated as a potential tool to predict heart disease in chimpanzees. However, the biomarkers appear to be species specific and related to the type of pathology causing heart disease. Cardiac troponin, BNP and several other biomarkers are being evaluated by a collaborative group lead by Michael Lammey and John Ely at the Alamorgordo Primate Facility. This project is a collaborative effort between Charles River and Yerkes Primate Center to help characterize the cardiac biomarker profile in chimpanzees. Within the last year approximately 10 chimps have had serum collected for biomarker analysis in conjunction with EKG and echocardiography performed by either a boarded veterinary cardiologist or a human cardiologist. The biomarker samples have been shipped to UC Davis for analysis and the data will be correlated with cardiac examination results.