BIOMARKERS FOR PRECLINICAL PARKINSON?S DISEASE

临床前帕金森病的生物标志物

基本信息

  • 批准号:
    8357570
  • 负责人:
  • 金额:
    $ 3.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-08-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Parkinson's disease is a progressive neurodegenerative disorder that starts many years prior to the appearance of the first motor symptoms. Thus, if one could intervene early in the disease process to slow down or reverse the progressive degeneration of midbrain dopaminergic neurons, it could have a significant impact on the development of the disease. The goal of this project is to identify preclinical biomarkers that would give the opportunity to pre-treat at risk patients with neuroprotective therapeutic drugs, which could significantly delay or even prevent the death of dopaminergic neurons and the development of motor deficits. In collaboration with Dr Jing Zhang at the University of Washington, this project aims at identifying such biomarkers using proteomics approach from the serum, cerebrospinal fluid and brain tissue in MPTP-treated monkeys. Although no data have yet been collected in this project, a total of 10 monkeys have been treated with MPTP until they reach about 30-40% ("asymptomatic group") or 70-80% ("symptomatic group") striatal dopamine loss, as measured using PET scan imaging for dopamine transporter ligands. Another group of animals, used as controls, was injected with vehicle. After they have reached the required level of striatal dopamine denervation, spinal taps and serum draw were performed before the animals were sacrificed and the brain tissue will be used for proteomics measurements. The results of these monkey studies will be compared with those gathered from serum and CSF measurements collected from at risk patients. Together, these findings could provide the first evidence for the characterization of biomarkers that could predict the development of Parkinson's disease in humans.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Yoland Smith其他文献

Yoland Smith的其他文献

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{{ truncateString('Yoland Smith', 18)}}的其他基金

Connectome of Motor Corticofugal Neurons in Parkinsonian Monkeys
帕金森猴运动皮质神经元的连接组
  • 批准号:
    10284849
  • 财政年份:
    2021
  • 资助金额:
    $ 3.29万
  • 项目类别:
Connectome of Motor Corticofugal Neurons in Parkinsonian Monkeys
帕金森猴运动皮质神经元的连接组
  • 批准号:
    10495224
  • 财政年份:
    2021
  • 资助金额:
    $ 3.29万
  • 项目类别:
Pathophysiology of the Pedunculopontine Nucleus in Parkinson's Disease
帕金森病桥脚核的病理生理学
  • 批准号:
    10213844
  • 财政年份:
    2017
  • 资助金额:
    $ 3.29万
  • 项目类别:
Pathophysiology of the Pedunculopontine Nucleus in Parkinson's Disease
帕金森病桥脚核的病理生理学
  • 批准号:
    9975917
  • 财政年份:
    2017
  • 资助金额:
    $ 3.29万
  • 项目类别:
Pathophysiology of the Pedunculopontine Nucleus in Parkinson's Disease
帕金森病桥脚核的病理生理学
  • 批准号:
    9404759
  • 财政年份:
    2017
  • 资助金额:
    $ 3.29万
  • 项目类别:
A2AR/MGLUR5 ANTAGONIST COMBINATION ANTIPARKINSONIAN THERAPY IN MPTP MONKEYS
A2AR/MGLUR5 拮抗剂联合抗帕金森病治疗 MPTP 猴
  • 批准号:
    8357543
  • 财政年份:
    2011
  • 资助金额:
    $ 3.29万
  • 项目类别:
GABA-B RECEPTORS AND PARKINSON'S DISEASE
GABA-B 受体与帕金森病
  • 批准号:
    8357385
  • 财政年份:
    2011
  • 资助金额:
    $ 3.29万
  • 项目类别:
THE THALAMOSTRIATAL SYSTEM IN PRIMATES
灵长类动物的丘脑纹状体系统
  • 批准号:
    8357447
  • 财政年份:
    2011
  • 资助金额:
    $ 3.29万
  • 项目类别:
ANATOMICAL AND PHYSIOLOGICAL CHARACTERIZATION OF THE THALAMOSTRIATAL SYSTEM
丘纹系统的解剖学和生理学特征
  • 批准号:
    8357545
  • 财政年份:
    2011
  • 资助金额:
    $ 3.29万
  • 项目类别:
MGLUR4 AS THERAPEUTIC TARGET IN PARKINSON?S DISEASE
MGLUR4 作为帕金森病的治疗靶点
  • 批准号:
    8357572
  • 财政年份:
    2011
  • 资助金额:
    $ 3.29万
  • 项目类别:

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