Rapid MRI Method of Assessing Joint Degeneration
评估关节退化的快速 MRI 方法
基本信息
- 批准号:8102161
- 负责人:
- 金额:$ 24.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-01 至 2013-06-30
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAmericanArthroscopyBiological MarkersCadaverCartilageDataDatabasesDegenerative polyarthritisDiseaseDisease ProgressionFaceFunctional ImagingHealthcareHumanImageImaging DeviceImaging TechniquesInstructionInvestmentsJointsKnee OsteoarthritisKnee jointLifeLongevityLongitudinal StudiesMagnetic ResonanceMagnetic Resonance ImagingMeasuresMethodsOrganPainPathologyPatientsPhysiologicalPopulationProcessProtocols documentationReference StandardsResearchResolutionScanningStructureSystemTechniquesTestingTherapeutic AgentsTimeUnited StatesUnited States National Institutes of HealthWaterarticular cartilagebasecostcost effectiveimaging modalityimprovednew technologynovel strategiesresearch study
项目摘要
DESCRIPTION (provided by applicant): While advances in healthcare have extended the lifespan in the United States, these advances have also meant that nearly all Americans will face the debilitating effects of osteoarthritis (OA) at some point in life. The lack of progress in developing successful therapeutic agents for OA has forced new approaches to researching this degenerative process. These new approaches appreciate that it is important to investigate not just articular cartilage, but the interactions which occur between all joint structures in patients with OA. Investments in longitudinal studies such as the NIH supported Osteoarthritis Initiative aim to develop multifaceted databases to track the progression of OA in large subject populations in hopes that this data will be useful in developing and testing new hypotheses for unraveling the disease. Magnetic resonance (MR) imaging methods serve as important surrogate biomarkers of disease progression in longitudinal OA studies such as the Osteoarthritis Initiative. However, given the constraints of cost and patient tolerance, MR examination times in OA research studies are generally limited to only 30 to 45 minutes. The need to assess all joint structures, known as "whole-organ" joint assessment and common to most OA imaging-based research, requires that a disproportionate amount of the imaging time be devoted to acquiring several morphologic imaging scans in different imaging planes. This results in limited time to incorporate physiologic imaging techniques into research protocols which can detect changes in cartilage composition prior to cartilage volume loss. The prospects for slowing or even stopping early OA are generally seen to be much stronger than slowing established OA, and thus the emphasis on physiologic imaging methods is growing. This project aims to develop a high resolution imaging tool for rapid "whole organ" assessment and cartilage volume analysis of the knee joint for use in OA research studies. The acceleration of morphologic joint imaging will allow sufficient time to incorporate physiologic cartilage imaging methods into research protocols, reduce research costs, and improve subject comfort.
RELEVANCE (See instructions): In this project, we will develop a rapid MR imaging method for evaluating all joint structures which can cause pain in patients with knee osteoarthritis (OA). Our single imaging method will replace multiple imaging methods currently used in OA research studies. Our new technology will improve patient comfort, reduce research costs, and allow sufficient time to add new imaging techniques sensitive to early cartilage breakdown into research protocols...
描述(申请人提供):虽然医疗保健的进步延长了美国人的寿命,但这些进步也意味着几乎所有美国人在一生中的某个时候都将面临骨关节炎(OA)的衰弱影响。在开发成功的骨性关节炎治疗剂方面缺乏进展,迫使人们采用新的方法来研究这种退变过程。这些新的方法认识到,不仅要研究关节软骨,而且要研究骨关节炎患者所有关节结构之间的相互作用。对纵向研究的投资,如NIH支持的骨关节炎倡议,旨在开发多方面的数据库,以跟踪大量受试者人群中骨性关节炎的进展,希望这些数据将有助于开发和测试揭开疾病的新假说。磁共振(MR)成像方法在骨性关节炎倡议等纵向骨关节炎研究中作为疾病进展的重要替代生物标记物。然而,考虑到成本和患者耐受性的限制,OA研究中的MR检查时间通常被限制在30到45分钟。评估所有关节结构的必要性被称为“全器官”关节评估,在大多数基于OA的成像研究中很常见,这要求将不成比例的成像时间投入到获取不同成像平面的几种形态成像扫描上。这导致将生理成像技术结合到研究方案中的时间有限,这些技术可以在软骨体积丧失之前检测软骨成分的变化。减缓甚至停止早期骨性关节炎的前景通常被认为比减缓已建立的骨性关节炎的前景要强得多,因此对生理成像方法的重视正在增长。本项目旨在开发一种高分辨率的成像工具,用于膝关节的快速“整体器官”评估和软骨体积分析,以用于骨关节炎的研究。形态关节成像的加速将为将生理性软骨成像方法纳入研究方案提供充足的时间,降低研究成本,并提高受试者的舒适度。
相关性(见说明):在这个项目中,我们将开发一种快速磁共振成像方法来评估所有可能导致膝骨性关节炎(OA)患者疼痛的关节结构。我们的单一成像方法将取代目前在OA研究中使用的多种成像方法。我们的新技术将改善患者的舒适度,降低研究成本,并允许有足够的时间将对早期软骨破坏敏感的新成像技术添加到研究方案中。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rapid MRI Method of Assessing Joint Degeneration
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7925244 - 财政年份:2010
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